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CRISPR/Cas9 gene-editing shows promise for improving sheep and goat breeding but faces challenges with efficiency and accuracy.

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

The document discusses various skin disorders and new therapeutic approaches.

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.

Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.

Nanotechnology is improving drug delivery and targeting, with promising applications in cancer treatment, gene therapy, and cosmetics, but challenges remain in ensuring precise delivery and safety.

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

Increasing Rps14 helps grow more inner ear cells and repair hearing cells in baby mice.

miRNA-based therapies show promise for treating skin diseases, including hair loss, in animals.

Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Efficient delivery systems are needed for the clinical use of CRISPR-Cas9 gene editing.

Activating the Sonic hedgehog gene in mice can start the hair growth phase.

Researchers found a safe and effective way to pick genetically modified skin cells with high growth potential using CD24.

Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.

Hair restoration has evolved from surgery to drugs to potential gene therapy, with improved results and ongoing research driven by high demand.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.

Melatonin affects certain genes and pathways involved in cashmere goat hair growth.

Advanced therapies like gene, cell, and tissue engineering show promise for hair regrowth in alopecia, but their safety and effectiveness need more verification.

Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.

Researchers used CRISPR/Cas9 to create a goat with a gene that increased cashmere production by 74.5% without affecting quality.

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

Epidermal stem cells show promise for future dermatology treatments due to ongoing advancements.

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

A hospital outbreak of catheter infections in calves was caused by a bacteria from a beef herd, leading to longer hospital stays, more drug use, and calf deaths.

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.

Liposomes show promise for delivering CRISPR for gene editing but face challenges like delivery efficiency and safety concerns.

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.