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This study found that the progesterone metabolite 3α-THP increased the proliferation and gene expression of human glioblastoma cells, suggesting a role in tumor progression.

In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.

This study found that intracutaneous injections of nandrolone phenylpropionate specifically induced local epidermal thickening and increased sebaceous gland volume in female hairless hamsters, independent of a dermal inflammatory response.

This study determined the crystal structure and conformation of synthesized 17x-Acetoxy-pregn-4,6-diene-3,20-dione, revealing specific molecular interactions and structural details in an orthorhombic crystal system.

In this study, the synthesis and testing of new pyrroloquinoline derivatives identified compound 7p, which showed low micromolar cytotoxic activity against MCF-7 and HeLa cells, highlighting its potential for development into a potent anticancer agent.

Using mirabegron and solifenacin together is safe and more effective for treating overactive bladder than using either drug alone.

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.

This review discusses the historical development, mechanisms of action, and potential new clinical applications of the drug cepharanthine, highlighting its multi-faceted pharmacological properties; it reports no new clinical results.

This study reports that the dye peri-xanthenoxanthene (PXX) can act as an efficient photocatalyst for various radical reactions, including complex dual catalytic processes and the synthesis of an investigational drug intermediate.

This study found that pre-treatment with the neurosteroid allopregnanolone in mice reduced nicotine withdrawal symptoms, suggesting potential therapeutic benefits for nicotine dependence.

This study found that progesterone reduces neuronal injury from tributyltin exposure in rat hippocampal slices through a mechanism dependent on allopregnanolone and GABAA receptors.

This study found that Cannabidivarin (CBDV) promotes neuronal differentiation and inhibits oligodendrocyte maturation via TRPV1 modulation, highlighting its potential in neural stem cell research.

A new compound may effectively inhibit the enzyme linked to BPH and hair loss.

This review discusses the non-cosmetic uses of botulinum neurotoxin A, including its effectiveness for idiopathic hyperhidrosis and potential use for androgenic alopecia, and reports no new clinical results; the authors highlight the need for more clinical trials.

This study found that in rodent models, the ability of D1 dopamine receptor activation to impair sensory gating is facilitated by 5α-reductase type 1, which produces allopregnanolone.

This study found that GTx-024 significantly increased total lean body mass and improved physical function in healthy elderly men and postmenopausal women, suggesting potential use for muscle wasting conditions.

In this study, GTx-027, a selective androgen receptor modulator, significantly inhibited tumor growth in certain breast cancer models and showed good tolerance in a Phase II trial with postmenopausal women.

This study suggests that both the central biosynthesis and metabolism of progesterone to 3α,5α‐THP in the ventral tegmental area are crucial for facilitating lordosis in female rats.

This study indicates that progesterone’s anesthetic activity in PR knockout mice is not due to progesterone receptors but is partially mediated by the neurosteroid allopregnanolone through GABAA receptor potentiation.

This animal study found that berberine may alleviate benign prostatic hyperplasia by reducing inflammation and oxidative stress through inhibition of the NF-κB signaling pathway.

Nitrendipine and nifedipine effectively block muscle contractions, while papaverine relaxes them and minoxidil needs high amounts to work.

This study reports that Elvitegravir, a drug currently approved for other uses, shows potential as a neuro- and mitoprotective agent by attenuating mitochondrial damage caused by NMDA receptors in primary mouse cortical neurons.

This study identified the N-(iodopropenyl) derivative 13 as a promising candidate for development as a radioiodinated androgen receptor ligand due to its binding affinity.

This study found that the AabHLH112 transcription factor positively regulates the biosynthesis of β-caryophyllene, epi-cedrol, and β-farnesene in Artemisia annua.

This review discusses the phytochemistry, pharmacology, pharmacokinetics, and standardization of Forsythiae Fructus, detailing both unripe and ripe forms, but reports no new clinical results.

This study confirmed the antioxidant role of rosemary, suggesting its potential use in treating inflammatory and infectious skin conditions, but emphasizes that more large-scale controlled trials are necessary to fully understand its clinical impact.

This study systematically documented the ethnobotanical and ethnomedicinal knowledge from traditional healers in Addis Ababa, identifying 81 medicinal plants, including the endangered Echinops kebericho, used primarily for treating skin and general diseases.

This review reports that Dang Gui (Radix Angelica sinensis) possesses bidirectional immunoregulatory effects, enhancing immune cell proliferation and function, and may benefit immune-related diseases such as cancer and anemia. It also evaluates regulatory and safety aspects, aiming to guide future research and clinical use.

This review compiles evidence indicating that rosemary essential oil may enhance cognitive function, sleep quality, mood, and pain management in aromatherapy; however, it also notes potential allergic reactions, emphasizing caution in its use.