Anesthetic Effects of Progesterone Are Undiminished in Progesterone Receptor Knockout Mice

    January 2005 in “ Brain Research ”
    Doodipala Samba Reddy, Leigh Ann Apanites
    Studysummary This study indicates that progesterone’s anesthetic activity in PR knockout mice is not due to progesterone receptors but is partially mediated by the neurosteroid allopregnanolone through GABAA receptor potentiation.
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    Research cited in this study 4

    1. Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice Neuropharmacology · 2004
    2. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004
    3. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002
    4. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997

    Related research 2

    1. Relating Neurosteroid Modulation of Inhibitory Neurotransmission to Behavior Journal of Neuroendocrinology · 2021
    2. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004