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Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.

Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

New compounds may soon be tested to treat excessive hair growth in women.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

These drugs cause hair growth without affecting testosterone or adrenal hormones.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

New compounds can block testosterone effects in rats and might help treat conditions like prostate cancer and acne.

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

The compounds tested could potentially treat hair loss and alopecia.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

Dutasteride caused more penile tissue changes than finasteride, possibly increasing erectile dysfunction risk.

Finasteride may reduce prostate bleeding by lowering blood vessel growth factor levels and blood vessel density in certain prostate areas.

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Finasteride temporarily lowers male rat fertility without affecting libido.