104 citations
,
May 2019 in “F1000Research” This review discusses recent research on male infertility causes and treatments, emphasizing the need for further understanding of idiopathic sperm abnormalities and molecular factors to improve patient outcomes; it reports no new clinical results.
26 citations
,
May 2016 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that mice lacking sPLA2-IIE had distinct skin abnormalities, particularly affecting hair follicles, highlighting the differing roles of sPLA2 isoforms in mouse skin.
24 citations
,
February 2011 in “The American journal of pathology” This study found that AIRE, a usually nuclear protein, is expressed in the cytoplasm of human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17, potentially impacting ectodermal abnormalities in APECED syndrome.
This research highlighted varying findings on the use of daily emollients for preventing atopic dermatitis in infants, with one study noting a reduction in incidence, while another found no preventive effect.
69 citations
,
January 2015 in “Cell & tissue research/Cell and tissue research” Keratin mutations cause skin diseases and could lead to new treatments.
3 citations
,
March 2023 in “International journal of molecular sciences” This review discusses the patterns and regulatory mechanisms of keratin expression in various biological conditions and reports no new experimental results.
July 2026 in “Scientific Reports” This study found that wool felting in Ukrainian Carpathian Mountain sheep is linked to significant changes in fatty acid composition, particularly highlighting a decrease in 18-methyleicosanoic acid in bound lipids, suggesting it as a potential marker for cuticle lipid layer damage during felting.
166 citations
,
July 1999 in “American Journal Of Pathology” This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.
81 citations
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March 2006 in “Journal of Investigative Dermatology” Mutations in the DSG4 gene cause specific hair and scalp issues.
40 citations
,
July 2019 in “Journal of Investigative Dermatology” In this study, knockout mice lacking the Cyp4f39 gene showed severe skin barrier dysfunction and high early mortality, suggesting its critical role in skin barrier formation and insights into ichthyosis pathogenesis.
29 citations
,
August 2011 in “PubMed” This study found that selected polymeric pretreatments on hair can significantly reduce breakage and protect against thermal damage from hot flat irons by maintaining cuticle integrity and moisture.
20 citations
,
August 2007 in “Molecular therapy” This study found that inducing hair follicles into the anagen-onset stage in mice enhances the immune response to a topically applied DNA vaccine against anthrax.
20 citations
,
July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
July 2026 in “Frontiers in Pharmacology” This study assessed pharmacogenomic variants and chemotherapy-related toxicity profiles in Tanzanian children with cancer, reporting notable genetic diversity that may influence toxicity but did not evaluate genotype-toxicity associations.
May 2026 in “Archives of Dermatological Research” This study found that treating human hair with vitamin E and γ-oryzanol significantly reduced UV-B-induced structural damage, with γ-oryzanol providing greater protection, especially in female hair samples. The findings highlight these compounds' potential as cost-effective solutions for preserving hair integrity against UV damage.
May 2026 in “Journal of Health Sciences and Medicine” This study found that biotinoyl tripeptide-1-loaded solid lipid nanoparticles significantly improved thermal protection in hair, enhancing cuticle integrity and resistance to heat damage, compared to control samples.
February 2026 in “Probiotics and Antimicrobial Proteins” Modifying gut bacteria with pro- and postbiotics may help treat hair loss.
September 2024 in “Meditsinskiy sovet = Medical Council” This article reports a rare case of toxic keratitis in a patient due to excessive intake of vitamin A, highlighting hypervitaminosis A risks such as severe eye conditions and systemic health issues, especially with cumulative doses exceeding therapeutic levels.
April 2023 in “Journal of Investigative Dermatology” In this study using a mouse model of Pemphigus vulgaris, researchers found that loss of desmoglein 3 adhesion in hair follicle stem cells triggers a regenerative program restoring stem cell function, requiring Hedgehog pathway suppression.
294 citations
,
February 2011 in “Cell” Nephronectin helps attach muscle cells to hair follicles.
10 citations
,
January 2019 in “International Immunology” This review discusses the interactions between immune cells and the skin epithelium and their impact on maintaining barrier function, emphasizing the potential to enhance epithelial barrier function in inflammatory diseases.
561 citations
,
April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
182 citations
,
May 2003 in “Development” This study found that Myc activation in mouse epidermis impairs keratinocyte adhesion and motility by downregulating extracellular matrix and cytoskeleton proteins, affecting hair lineage differentiation.
87 citations
,
February 2000 in “Journal of Investigative Dermatology” Stem cells in developing hair follicles move to specific areas as they mature.
52 citations
,
October 2005 in “Journal of Investigative Dermatology” This study found that human hair follicle stem cells formed more colonies and adhered more rapidly, while transit-amplifying cells showed significantly greater mobility.
51 citations
,
February 2004 in “Journal of Investigative Dermatology” MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.
41 citations
,
July 2019 in “Clinical Cosmetic and Investigational Dermatology” This paper explores the complex immune processes and cellular diversity that enable the skin to heal and resist invasion, and highlights its potential as a model for studying regeneration.
35 citations
,
October 2013 in “Journal of Dermatological Science” This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.
25 citations
,
October 2005 in “PubMed” This study found that keratin 19 and nuclear galectin-1 binding can transiently express in interfollicular epidermal cells after adhesion, suggesting keratin 19 should not be solely used as a stem cell activity marker.
24 citations
,
August 2022 in “Immunity” This study found that control of Demodex mite colonization in mice required skin ILC2s and IL-13, highlighting their role in maintaining HF integrity and limiting mite overgrowth.