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This study found that bulge-derived keratinocytes from human follicles were more resistant to differentiation compared to epidermal keratinocytes, possibly due to WIF-1 involvement.

This study found that cells isolated from human scalp hair follicles proliferated well in a specific culture medium and possessed keratins characteristic of hair-forming cells.

This study identified and sequenced several keratin cDNA clones showing distinct expression patterns in mouse epithelia, with in situ hybridization highlighting differences in keratin distribution between normal and hyperproliferative tissues.

This study found that the SVpgC2a keratinocyte cell line, used as a model for dysplastic epithelium, showed increased apoptosis, proliferation, and aberrant keratin expression compared to normal keratinocytes from buccal mucosa.

This study found that the keratin expression in basal cell carcinoma resembles that of the pilosebaceous apparatus, with uniform presence of certain keratins in all cases.

The researchers reported that basal cell carcinoma tumor cells strongly express keratins typical of basal keratinocytes and some hair follicle components but lack differentiation markers, suggesting a follicular or pluripotent stem cell origin.

This study demonstrated that hair follicle bulge stem cells can form epidermis in a tissue-engineered skin model, highlighting the significance of K5/K17 filaments in slow-cycling stem cell subsets.

This study found that Basonuclin 1 knockdown in human primary keratinocytes significantly reduces cell proliferation and affects migration, indicating its role in coordinating the re-epithelization phase of wound healing.

The researchers reported that iPSCs derived from Sendai virus reprogrammed blood cells can mature into functional keratinocytes for up to 60 days, potentially offering new approaches for DEB treatment.

This study demonstrates that keratinocyte cell lines derived from cultured hair follicles can fully differentiate in organotypic skin models, offering a minimally invasive alternative to obtaining keratinocytes for research.

This study found that Thy1+ keratinocytes in the basal layer of the interfollicular epidermis play a crucial role in epidermal homeostasis and wound repair, with their ablation impairing these processes.

This study used single-cell RNA sequencing to identify at least nine subpopulations of keratinocytes in human neonatal epidermis, revealing unexpected heterogeneity and complex differentiation trajectories.

Basal cell carcinoma shows keratin patterns similar to undifferentiated hair follicle cells.

This study reports that the monoclonal antibody BKN-1 specifically stained basal cell epithelioma cells and certain normal skin structures, indicating a similarity in keratin expression between the tumor and follicular epithelium below the isthmus portion.

This study describes a method for serially cultivating adult human hair follicle keratinocytes using a specific growth substrate and cryogenic storage, enabling subculture and immunofluorescence studies.

This study suggests that basonuclin in keratinocytes is likely a regulatory molecule linked to maintaining proliferative capacity and preventing terminal differentiation rather than a cell cycle marker.

This study found that BRG1 is crucial for keratinocyte migration during skin wound healing, as its suppression impairs wound closure by inhibiting migration without affecting cell proliferation or apoptosis.

This study found that keratinocyte stem cells in mouse skin are closely related to side population or BCRP1-positive cells based on their localization and marker expression.

This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.

This study reported that gain-of-function mutations in TRPV3 lead to hair loss in mice by disrupting inner root sheath keratinocyte differentiation, ultimately causing follicular keratinocyte stem cell exhaustion and permanent follicle disruption.

This paper presents a protocol for differentiating human-induced pluripotent stem cells into keratinocyte progenitor cells and keratinocytes, suggesting potential applications for hair follicle restoration and burn or ulcer therapy.

This study found that hyperproliferative stimuli dysregulated the balance of stem cell divisions in keratinocytes, suggesting potential treatment strategies for both benign and cancerous hyperproliferative diseases.

This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.

This study found that hHbl gene expression is localized in the cortical cells of the human hair shaft and is notably high in pilomatricoma cells transitioning to hair shaft keratinocytes.

This study found that basal keratinocytes in engineered skin substitutes showed a proliferative phenotype and potential for long-term replication, which may enhance wound healing stability.