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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Ruxolitinib significantly improves multiple autoimmune conditions in APS-1 patients.

Genes and hormones cause hair loss, with four genes contributing equally.

Bezafibrate treatment improved skin and spleen health in aging mice but didn't extend lifespan.

The conclusion is that early diagnosis of skin signs linked to diseases like Lupus, Dermatomyositis, and Rheumatoid Arthritis is crucial to prevent serious complications.

Cyclosporin doesn't stop hair loss.

Mutations in the KRT85 gene cause hair and nail problems.

Certain drugs change freshwater snail shells to a "banana" shape.

The risk of skin tumors becoming malignant depends on the specific skin cell type affected.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Using low-dose IL-2 to increase regulatory T cells might be a safe way to treat type 1 diabetes without severe side effects.

Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.

The research reveals how early embryonic mouse skin develops from simple to complex structures, identifying various cell types and their roles in this process.

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

The study concludes that mutations in the AEBP1 gene can cause a form of Ehlers-Danlos syndrome and should be considered in diagnosis.

Rabbits lacking the Hoxc13 gene show similar hair and skin issues to humans with ECTD-9, making them good for research on this condition.

Low TRPS1 expression in skin and hair cells is linked to hair problems in Trichorhinophalangeal syndrome.

Hair microscopy is useful for diagnosing hair disorders, but clear definitions are needed for accurate genetic analysis.

People with Mucopolysaccharidoses often have skin problems like thick skin and extra hair, and recognizing these can help diagnose and treat the condition early.

Activating TLR5 in the gut can extend lifespan and improve health in aged mice.

Keratin gene expression helps understand different types of skin cells and their development, and should be used carefully as biological markers.

Hyaluronic acid injections improve skin thickness and quality, protecting against aging in rats.

Older mice healed wounds better but lost more weight and might have weaker immune systems afterward.

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

Sphynx cats are hairless and Devon Rex cats have curly hair due to specific genetic mutations.