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Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Liraglutide caused significant weight loss in some obese women with PCOS, especially those with severe obesity and insulin resistance.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

The document concludes that Rabson-Mendenhall syndrome requires novel treatments for insulin resistance and emphasizes the importance of dental care in affected patients.

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

Adolescents with abnormal uterine bleeding often have polycystic ovarian syndrome and insulin resistance.

N-acetylcysteine was more effective and had fewer side effects than metformin for improving insulin resistance in women with PCOS.

Eating a high inositol diet significantly improves insulin resistance and hormone levels in women with PCOS.

Some plant-based treatments may help with ovary function, insulin resistance, and excess male hormones in PCOS, but more research is needed to confirm their safety and effectiveness.

Higher leptin and lower vitamin D levels may contribute to male pattern baldness.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Women with PCOS often have more body hair, acne, and skin darkening, and these signs are linked to metabolic issues like insulin resistance and high cholesterol.

Blocking the ATX-LPA pathway may improve insulin sensitivity and mitochondrial function in obesity.

Many young Italian women have hyperandrogenic disorders like PCOS, which are linked to age, body weight, and insulin resistance.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

High levels of TNF-α may contribute to obesity and insulin resistance in PCOS, but not due to the C850T genetic variation.

Selenium might help with insulin resistance and cholesterol in PCOS, but more research is needed to confirm its benefits.

Women with PCOS have more depression and stress due to high androgen levels, not obesity or insulin resistance.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

Resistance training improved BMI and menstrual regularity more in women with PCOS than aerobic training.

Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.

Women with Polycystic Ovary Syndrome (PCOS) have lower levels of a substance called DIAPH1 in their blood, which is linked to changes in sugar metabolism and insulin resistance.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Depression severity is not linked to PCOS markers like BMI, insulin resistance, or testosterone levels.

The document suggests various treatments for PCOS, including medication for menstrual issues, insulin resistance, and excess hair, as well as fertility treatments, while highlighting the need for personalized care and lifestyle changes.