Depression, Higher Level of Tension Induction, and Impaired Coping Strategies in Response to Stress in Women with PCOS Correlate with Clinical and Laboratory Indices of Hyperandrogenism and Not with Central Obesity and Insulin Resistance

    August 2024 in “ Archives of Women s Mental Health ”
    Edyta Dutkiewicz, Dominik Rachoń, Miłosz Dziedziak, Agnieszka Kowalewska, Joanna Moryś
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    TLDR Women with PCOS have more depression and stress due to high androgen levels, not obesity or insulin resistance.
    The study involving 42 women with PCOS and 39 healthy controls found that women with PCOS exhibited higher levels of depression, tension induction, and impaired coping strategies, which correlated with clinical and laboratory indices of hyperandrogenism (e.g., serum testosterone levels) rather than central obesity or insulin resistance. This suggests that the psychological challenges in women with PCOS are more closely related to hyperandrogenism than to metabolic factors.
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