Is Polycystic Ovarian Syndrome and Insulin Resistance Associated with Abnormal Uterine Bleeding in Adolescents?

In a study conducted in 2019 involving 43 females aged 12-18 years diagnosed with juvenile menorrhagia and 37 healthy female adolescents of the same age range, it was found that adolescents with abnormal uterine bleeding (AUB) are often diagnosed with secondary amenorrhea and polycystic ovarian syndrome (PCOS). The study also found that the group with a diagnosis of juvenile bleeding had higher rates of insulin resistance. The occurrence of regular menstrual cycles was significantly lower in the juvenile bleeding group (30.23%, p = 0.006), and secondary amenorrhea was significantly more likely to be recognized in this group of females (p = 0.03). The concentration of FSH was considerably lower (p = 0.0002) in the group of adolescents with AUB.