research Adipokines in the Skin and Dermatological Diseases
Adipokines affect skin health and could be targeted for treating skin diseases.
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90-120 / 1000+ resultsresearch Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ
Sex hormones, especially androgens, play a key role in causing acne.
research Expression of Signaling Components in Embryonic Eyelid Epithelium
Eyelid cells share signaling components but differ in pathway activity.
research Testosterone: The Male Sex Hormone
More research is needed to understand how testosterone is maintained in adult males.
research Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition
Certain mice without specific receptors or mast cells don't lose hair from stress.
research Evaluation of the Relationship Between Serum G Protein-Coupled Estrogen Receptors (GPER-1) Levels and the Severity and Duration of the Disease in Patients with Androgenetic Alopecia: A Case-Control Study
Higher GPER-1 levels are linked to more severe and shorter-duration androgenetic alopecia, suggesting GPER-1 as a potential treatment target.
research A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia
Researchers created a mouse model of a type of rickets that does not cause hair loss.
research Altered Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata
Increased Toll-like receptors in blood cells may contribute to alopecia areata and could be a target for new treatments.
research Rickets with Alopecia Signals Vitamin D Dependent Rickets Type II
A child with rickets and hair loss might have a rare type of rickets that doesn't improve much with usual vitamin D and calcium treatment.
research 3,3-Diphenylpentane Skeleton as a Steroid Skeleton Substitute: Novel Inhibitors of Human 5α-Reductase 1
A new compound effectively inhibits human 5α-reductase 1.
research The Emerging Role of Janus Kinase Inhibitors in the Treatment of Autoimmune and Inflammatory Diseases
Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.
research Three Cases of Alopecia Following Clinical Islet Transplantation
Some patients developed hair loss after islet cell transplant possibly due to their immune-suppressing medications.
research The Human Skin as a Hormone Target and an Endocrine Gland
Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.
research Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions
Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
research Regulation of Hair Shedding by the Type 3 IP3 Receptor
The type 3 IP3 receptor is important for controlling hair loss and growth.
research The Influence of Interferon on Healthy and Diseased Skin
Type I interferons play a key role in the development of various skin diseases.
research Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin
Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.
research Steroid 5α-Reductase Inhibitors
New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.
research Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture
IL-1β inhibits human hair follicle growth.
research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors
New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
research Androgens and Hair Growth
Androgens can both increase and decrease hair growth in different parts of the body.
research Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles
Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.
research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?
Using neurohormones to control keratin can lead to new skin disease treatments.
research Clinical and Biological Impact of the Exposome on the Skin
Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.
research Management of Toxicities of Targeted Therapies
Targeted therapies for lung cancer are effective but require careful management of side effects to benefit patients.
research TGF-β Family Signaling in Stem Cells
TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.
research Steroid 5α-Reductase 2 Deficiency Leads to Reduced Dominance-Related and Impulse-Control Behaviors
Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.
research The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia
Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.
research GRHL3 Binding and Enhancers Rearrange as Epidermal Keratinocytes Transition Between Functional States
GRHL3 is important for controlling gene activity in skin cells during different stages of their development.
research TLR3 Signaling Modulates Immunomodulatory Property of Human Periodontal Ligament Stem Cells
TLR3 signaling enhances the immunosuppressive properties of human periodontal ligament stem cells.