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Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The normal human prostate does not significantly affect blood DHT levels.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

Finasteride effectively treats hirsutism in women, but more research needed for long-term results.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

Mouse genital development depends on male or female hormones for specific features.

Androgens like testosterone may help treat traumatic brain injury by reducing mitochondrial stress and inflammation.

Certain drugs that block specific enzymes can help treat prostate diseases.

Dutasteride safely promotes hair growth and reduces hair loss, with mild side effects.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

Diane 35 plus finasteride is more effective in reducing hair growth and androgen levels, but may decrease libido.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Androgenetic alopecia is influenced by various factors and can be treated with medications, procedures, and non-drug methods.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Hyperandrogenism is a common hormonal disorder in women, often linked to PCOS.

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

Compound 4 is a promising treatment for hair loss with low toxicity.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Low testosterone does not prevent prostate cancer in men with type 1 diabetes.