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In this study, researchers developed de novo designed hetero-bifunctional proteins as an alternative approach for targeted protein degradation, successfully targeting BCL-xL for degradation in cells and inducing apoptosis, which may expand the range of addressable E3 ligases and disease targets.

This study compared the microscopic treatment zones created by different fractional lasers and radiofrequency in swine skin, finding distinct patterns and damage levels for each technology.

In this study, researchers found that the health state utility of moderate facial angiofibroma in Tuberous Sclerosis Complex patients is significantly lower compared to almost-clear facial angiofibroma, indicating that treatment for the condition can substantially improve quality of life.

This study suggests that Thyroxine (T4) may promote key features of human skin wound healing, such as re-epithelialization and angiogenesis, in an ex vivo model.

This review examines ultrasound-assisted and laser-based transdermal drug delivery technologies, highlighting their success in enhancing drug penetration through the skin but also noting challenges such as parameter optimization, potential skin irritation, and high equipment costs.

This study found that introducing rat ornithine transcarbamylase gene into spf-ash mice improved liver and intestinal enzyme activity and normalized some metabolic indicators.

This case report describes the first confirmed instance of trichodysplasia spinulosa in a child with Down syndrome and leukemia, linking it to the TS-associated polyomavirus.

This review discusses recent advancements in light-based bioelectronic devices for health monitoring and therapy, summarizing key technologies and highlighting challenges and opportunities without reporting new clinical results.

This review discusses the heterogeneity of Tregs in normal and tumor environments, emphasizing the complexity of targeting tumor-resident Tregs while maintaining systemic immune tolerance, but reports no new findings.

This overview details the Dermatologic Surgery journal's extensive coverage of dermatologic surgery topics, including cosmetic and reconstructive procedures, but it reports no new research findings.

This study found that trichoscopy can effectively identify specific patterns associated with Vitamin B12, Vitamin D3, and serum ferritin deficiencies in patients with Telogen Effluvium, offering a non-invasive alternative to blood tests for early diagnosis and management.

This study demonstrated that the tracheal xenotransplant procedure is an effective technique for assessing the invasiveness of epidermal keratinocytes and studying factors affecting hair follicle formation.

This case series found that combining ablative fractional resurfacing and acoustic pressure ultrasound with triamcinolone treatment led to complete recovery in patients with areata alopecia.

This report describes a case where topical 0.1% tretinoin cream successfully controlled Fox-Fordyce disease in a 21-year-old woman.

This study found that periodic intratesticular PRP administration may slightly enhance testicular development in male lambs, indicated by increased testicular blood flow, length, and reduced resistance index compared to saline.

This study found that applying supraphysiologic doses of topical T3 significantly accelerated wound healing in mice compared to a control vehicle, suggesting its potential as a cost-effective wound treatment.

In this open-label trial, Tofacitinib was well tolerated and improved IFN and cytokine scores, as well as overall skin pathology, in individuals with Down syndrome and immune skin conditions.

This narrative review reported that direct-to-consumer teledermatology improves access to care, adherence, and patient satisfaction for treating male androgenetic alopecia, but may lead to higher drug costs.

This study reports that a 21-year-old male with alopecia totalis responded positively to the JAK inhibitor tofacitinib, achieving complete hair regrowth after six months of treatment without significant side effects, though further research is needed to evaluate long-term efficacy.

Playing computer games for a long time could increase the risk of deep vein clots in kids.

In this study, Makarova et al. found that topical vitamin D3 significantly delayed basal cell carcinoma development in UVR-exposed, BCC-prone mice, while oral vitamin D3 supplements did not prevent carcinogenesis, suggesting a potential role of UV-induced vitamin D3 in inhibiting tumor growth.

This study found that loss of the Pten gene in Lgr5+ hair follicle stem cells promoted squamous cell carcinoma formation through the Akt/β-catenin signaling pathway.

Tofacitinib might be used to treat hair loss.

This article discusses the potential uses of plasma therapy for various conditions, including wound healing and Covid-19, but presents no new clinical findings; the authors highlight its increased demand since the Covid-19 outbreak.

This paper reviews the use of interferons, particularly alfa interferon, in treating cutaneous T-cell lymphoma, noting its substantial efficacy both alone and in combination therapies with predictable, generally well-tolerated side effects.

This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.