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This study found that specific proteins associated with fiber structure, hair growth, and fatty acid synthesis, including the DSC2 gene, may influence wool and hair characteristics in sheep and goats.

In this study, tebentafusp-tebn improved overall survival in patients with metastatic uveal melanoma compared to standard therapies, despite higher rates of significant adverse events.

This article discusses trichotillomania and trichoteiromania, focusing on their clinical presentation, main trichoscopic features, and similarities in hair loss patterns but reports no new research findings.

Trichohyalin in hair can trigger immune attacks in alopecia areata.

This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.

This study found that trans-3,4'-Dimethyl-3-hydroxyflavanone reduces active TGF-beta2 levels in human keratinocytes, suggesting it may enhance hair growth by suppressing the TGF-beta2 activation pathway.

This study reports that a novel frameshift mutation in the HTRA1 gene in a CARASIL pedigree led to reduced HTRA1 protein and increased TGF-β1 expression, potentially causing severe CARASIL and peripheral small arterial disease.

This study found that trichothiodystrophic hair shows reduced and disoriented protein deposition in follicles, with both the cuticle and cortex affected, providing localized structural insights into keratin abnormalities.

This study found that activation of cannabinoid 1 receptors in human scalp hair follicles may limit excessive mast cell activation and maturation, suggesting a potential therapeutic strategy for managing MC-dependent skin diseases.

This study suggests that mast cells may play a role in stress-related hair loss associated with telogen effluvium.

This case report presents the first evidence of significant antigen presenting cells around hair follicles in a patient with alopecia due to active systemic lupus erythematosus.

This study found that sorafenib increased mast cell number and degranulation in skin, suggesting PI3K signaling and SCF production may underlie its adverse cutaneous reactions.

In this study, UVB irradiation increased mast cell degranulation only when skin was innervated, suggesting that the interaction between mast cells and nerve fibres may exacerbate solar elastosis by promoting dysfunctional dermal elastic fiber accumulation, but further research is needed for confirmation.

In this study, researchers used in silico mutagenesis to identify key calcium-binding sites influencing the stability of Rand protease from Bacillus subtilis, potentially enhancing its application in industries like leather dehairing by improving stability and eliminating the need for additional metal ions during the process.

This study developed PiSCES biosignatures that distinguished alopecia areata patients from controls, revealing enhanced basal TCR signaling and a potential disease-specific signaling network signature.

This study found that expressions of TLR-3, TLR-7, TLR-8, and TLR-9 were significantly higher in alopecia areata patients compared to healthy controls, indicating a potential role in disease autoimmunity.

In this study using mice with specific gene knockouts, both farnesyltransferase and geranylgeranyltransferase-I were found to be essential for the proliferation and survival of skin keratinocytes.

In this study, researchers found two non-synonymous SNPs in the TERT gene associated with mean wool staple strength in sheep, suggesting TERT as a potential candidate gene for improving wool traits.

In this study, hair shafts from trichothiodystrophy patients with ERCC2 mutations revealed abnormal cuticle structures and protein imbalances compared to normal hair shafts.

This case report describes an 18-year-old male with kerion celsi from Trichophyton tonsurans infection whose condition improved with terbinafine treatment, and highlights that although IL-17A expression increased in skin lesions, it was associated with disrupted antimicrobial peptide expression and severe inflammation, causing tissue damage.

In this study, overexpressing TSPO in the mouse hippocampal dentate gyrus led to significant anxiolytic and antidepressant-like effects, partly through increased allopregnanolone biosynthesis.

This study suggests that human trichohyalin may function as a flexible rod linking keratin intermediate filaments and as a scaffold protein in hair follicle and epidermis cell envelopes.

This study reports that a 190,000 molecular weight protein, identified as trichohyalin, may play a matrix role in the development of inner root sheaths in hair follicles.

In this case-control study, researchers did not find genome-wide significant genetic variants for trichotillomania, but cases had higher polygenic risk for psychiatric disorders and certain neuropsychiatric-associated copy number variants.

This study found that trichothiodystrophy can be diagnosed prenatally in the second trimester using an endoscopically-guided fetal eyebrow biopsy, with sulfur content analysis being the most reliable test.

A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.

This study suggests that TGF-alpha may function in an autocrine or juxtacrine manner rather than promoting cell proliferation during hair growth cycles in ferrets and sheep.