Genomic Analysis of Trichotillomania

This study investigates the genetic basis of Trichotillomania (TTM) through a genome-wide association study involving 101 European ancestry TTM cases and 488 ancestry-matched unaffected controls. Although no common variants reached genome-wide significance, TTM cases exhibited a higher polygenic risk for psychiatric disorders compared to controls. Additionally, copy number variants associated with neuropsychiatric disorders, such as deletions in NRXN1, CSMD1, and 15q11.2, were identified in TTM cases. These findings suggest a genetic component in TTM's etiology and indicate that larger studies may uncover specific risk genes.