TLDR Terbinafine effectively treated kerion celsi despite disrupted immune responses.
The document reported a case of kerion celsi in an 18-year-old male judo practitioner, characterized by alopecic patches and subcutaneous abscesses due to Trichophyton tonsurans infection. Despite initial treatment with oral itraconazole showing no effect, subsequent treatment with terbinafine was effective. A skin biopsy revealed infiltration of neutrophils, lymphocytes, and histiocytes, with abscesses around dilated hair follicles. Immunostaining indicated decreased expression of human β-defensin 2 (HBD-2) in the epidermis, despite an unexpected increase in interleukin-17A (IL-17A) expression around damaged hair follicles. This suggested a disorder in IL-17A-upregulated antimicrobial peptide expression, potentially leading to severe inflammation, tissue damage, and scarring in kerion celsi.
196 citations
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November 2014 in “PubMed” Tinea infections need proper diagnosis and treatment with topical or oral antifungals based on severity and location.
156 citations
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September 2014 in “British journal of dermatology/British journal of dermatology, Supplement” Accurate diagnosis and effective oral treatment are key to managing tinea capitis and preventing its spread.
February 2024 in “Medical mycology case reports” Unusual fungal structures were found in a boy's scalp infection, successfully treated with medication.
65 citations
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January 2005 in “American journal of clinical dermatology” Children with scalp fungal infections need proper diagnosis and treatment, usually with antifungal medications, and newer drugs may offer quicker recovery.
January 2025 in “Journal of Clinical Medicine” Unsanitary barber practices can spread scalp infections, treatable with oral antifungals.
245 citations
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March 2012 in “Journal of The American Academy of Dermatology” Dermatoscopy is useful for identifying different hair and scalp conditions and can reduce the need for biopsies.
January 2019 in “Open access journal of mycology & mycological sciences” The article concludes that proper antifungal treatment is essential for treating scalp fungal infections in children, and trichoscopy is useful for diagnosis and monitoring.
