12 citations,
September 2007 in “Wound repair and regeneration” Smad2/3-dependent TGF-β signaling increases during wound healing.
5 citations,
May 2004 in “International Journal of Cosmetic Science” Versican is important for hair growth and could help find new hair regrowth treatments.
42 citations,
March 2010 in “Endocrinology” Mice with human gene experienced hair loss when treated with DHT.
43 citations,
February 1999 in “Biochemical Journal” Overexpression of SSAT in mice causes hair loss, liver damage, and sensitivity to polyamine analogues.
233 citations,
July 1997 in “PubMed” High levels of ornithine decarboxylase can cause tumors in mouse skin.
Key genes for mink fur have been identified, aiding conservation efforts.
65 citations,
July 2006 in “Journal of biological chemistry/The Journal of biological chemistry” The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.
3 citations,
April 2016 in “Wound Repair and Regeneration” Researchers successfully transplanted hair follicles in mice, which survived well and helped in wound healing.
153 citations,
October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
April 2017 in “Journal of Investigative Dermatology” The BMP/Smads pathway and Id2 gene control hair follicle stem cells, affecting their rest and growth phases.
38 citations,
January 2016 in “Cell Death and Disease” The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.
May 2014 in “Journal of Investigative Dermatology” Scientists developed tools to observe hair regeneration in real time and assess skin health, using glowing mice and light-controlled genes.
1 citations,
March 2022 in “Journal of Dermatological Science” Adding TERT and BMI1 to certain skin cells can improve their ability to create hair follicles in mice.
28 citations,
December 2005 in “Oncogene” 163 citations,
October 2001 in “EMBO journal” Overexpressing follistatin in mice delays wound healing and reduces scar size.
67 citations,
September 2001 in “American Journal Of Pathology” Inhibiting ODC can prevent UV-induced skin cancer.
June 2006 in “Experimental dermatology” Hair follicle bulge cells are important for hair survival and help heal the skin after injury, which might be relevant for understanding hidradenitis suppurativa.
33 citations,
February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology” IGF-1 increases whisker growth in transgenic mice.
124 citations,
July 1997 in “Journal of Biological Chemistry” Overexpressing a specific enzyme in mice causes hair loss and female infertility.
81 citations,
January 2003 in “The FASEB Journal” Follistatin helps hair growth and cycling, while activin prevents it.
45 citations,
April 2016 in “Journal of Dermatological Science” The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.
8 citations,
November 2019 in “Clinical Science” High DHA levels delay wound healing and worsen skin repair quality.
54 citations,
February 2002 in “Carcinogenesis” Increasing SSAT makes skin more prone to cancer.
25 citations,
December 2007 in “Developmental biology” Clim proteins are essential for maintaining healthy corneas and hair follicles.
January 2004 in “Enshou saisei” Follistatin is important for hair growth and could help treat hair loss.
Researchers created a new mouse model, G4, that mimics human PCOS symptoms and links the condition to a specific gene.
338 citations,
April 2001 in “Current Biology” c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.
26 citations,
April 1998 in “Journal of Investigative Dermatology” Sunscreens with higher SPF and UVA filters offer the best protection against skin aging from UVA rays.
54 citations,
May 2001 in “Journal of Investigative Dermatology” Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.
52 citations,
May 1997 in “Journal of Biological Chemistry” High ornithine decarboxylase levels may lead to hair loss and cancer by increasing CK2 activity in the nucleus.