A Novel In Vivo Model for Evaluating Agents That Protect Against Ultraviolet A-Induced Photoaging

    Tsunemichi Takeuchi, Jouni Uitto, Eric F. Bernstein
    TLDR Sunscreens with higher SPF and UVA filters offer the best protection against skin aging from UVA rays.
    The study utilized a transgenic mouse model to evaluate the effectiveness of sunscreens in protecting against UVA-induced photoaging. The mice were exposed to PUVA to induce photoaging, and the study found that all tested sunscreens reduced CAT activity, indicating protection against UVA-induced damage. The combination of an SPF 15 sunscreen and a UVA filter provided the highest level of protection. The model demonstrated sensitivity and potential to simulate human cutaneous photoaging, highlighting the importance of UVA protection in sunscreens and suggesting that inflammation might play a role in elastin gene induction by UVA. The study emphasized the need for sunscreens with higher SPF ratings to incorporate more UVA protection.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 7 results

    Similar Research

    5 / 788 results
      Index

      research Index

      September 2019
      The document is a detailed guide on skin conditions and treatments for dermatologists.

      research Melasma, A Photoaging Disorder

      144 citations, December 2017 in “Pigment cell & melanoma research”
      Melasma is now considered a skin aging disorder caused by sun exposure in people with a genetic tendency, which impacts treatment and prevention approaches.
      Subject Index

      research Subject Index

      March 2014 in “Journal of The American Academy of Dermatology”
      The document lists various dermatology topics, treatments, and diagnostic methods.