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This study found that all-trans-retinoic acid (ATRA) inhibits mink hair follicle growth by reducing dermal papilla cell proliferation and inducing apoptosis, likely through the TGF-β2/Smad2/3 pathway.

The researchers reported that the antipsoriatic compounds 1,25-dihydroxy-vitamin D3 and calcipotriol thinned the living cell compartment in organotypic ORS cultures by accelerating the differentiation pathway rather than affecting proliferation.

This study demonstrates that Tp63-expressing epithelial stem cells from non-skin tissues can respond to skin morphogenetic signals and contribute to the formation of hair follicles, sebaceous glands, and epidermis.

This study found that using the OptoTrkA system to control TrkA activity with blue light enhanced proliferation, migration, and differentiation of hair-follicle-derived stem cells into neuronal and glial cells.

This article reviews mammalian skin epidermis as a model for studying stem cell regulation, noting the utility of in vitro and ex vivo platforms, but it reports no new empirical findings.

The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.

This review highlights that the RNA modification N⁶-methyladenosine (m⁶A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.

This study found that the purified compound VB1 from Vitex negundo seeds may reduce UVA-induced skin aging by targeting MAPK1 and demonstrated its potential in mice.

This study found that recombinant human hair keratin proteins K31 and K81 show greater potential for inducing skin cell differentiation compared to natural keratin coatings.

This review discusses the characteristics and potential applications of epidermal stem cells in dermatology, without providing new clinical results.

This study reported that an ATRA-loaded nanostructured lipid carrier gel (ATRA-NLC-Gel) improved symptoms of alopecia areata in mice by enhancing transdermal drug delivery, reducing skin irritation, and promoting hair regrowth through targeted follicle enrichment and pathway activation.

This study found that treating rat whisker follicle stem cells with retinoic acid and epidermal growth factor induced them to express synaptophysin, a marker of mature neurons, although there was a reduction in other neural markers, suggesting potential for neuro-regeneration applications.

This study found that zebrafish and stickleback fish use similar genetic programs for tooth regeneration, despite differences in their dental structures.

This study identified Activin A and its antagonist follistatin as crucial regulators of hair cell differentiation in mice, suggesting a local gradient of Activin A influences auditory sensory epithelium development.

This study identifies Activin A and follistatin as key regulators of hair cell differentiation in the mouse auditory sensory epithelium, influencing the timing and pattern of hair cell development.

This study found that stabilized beta-catenin is crucial for activating stem cell transition from quiescence to proliferation in hair follicles by influencing gene expression within the stem cell niche.

This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.

This study found that polycomb-group-mediated repression plays a key role in regulating hair follicle stem cell states and lineage progression by distinct mechanisms in adult mouse skin.

This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.

This study found that transcriptome profiling of cashmere goat skin revealed key genes and pathways involved in hair follicle initiation, differentiation, and maturation, which are critical for improving fleece production.

This article reviews recent advancements in understanding skin stem cells and their roles in maintaining epidermal homeostasis and repairing wounds, without presenting new experimental findings.

This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.

This review discusses the various roles of RANK signaling in bone remodeling, immune function, and epithelial differentiation, highlighting its potential involvement in cancer mechanisms; it reports no new clinical results.

This review discusses the regenerative processes of lizard tails, particularly focusing on the diversity in blastema development across different species, and reports no new findings.

This study found that upper wound fibroblasts are crucial for hair follicle regeneration during wound healing and suggests that these cells, along with papillary fibroblasts, migrate within the wound.

This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.

This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.

This study suggests that topical T3 can induce hair follicles to enter the growth phase and may reverse graying in mice, with in vitro results supporting enhanced hair shaft growth.

In this study, adipose-derived stem cells from superficial adipose tissue showed higher regenerative potential, and more macrophages were found in superficial than deep adipose tissue, potentially influenced by skin microbiota.

This study found that suspension culture was more effective than hydrogel-based systems for maintaining spheroid morphology and differentiation of human iPSC-derived definitive endoderm cells.