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In this study, researchers observed that Cuscuta reflexa extract mitigated inflammation and oxidative stress in testosterone-induced benign prostatic hypertrophy in Wistar rats, suggesting its potential as an adjunctive therapy for BPH.

This case report from the authors highlights a rare diagnosis of high-grade prostate cancer in a 35-year-old man, showing strong functional recovery and no detectable PSA one year after robotic-assisted radical prostatectomy despite the usual onset being significantly later in life.

In this study, Swedish men carrying the AR haplotype H2 were found to have a significantly lower risk of prostate cancer compared to those with the more common H1 variant.

Finasteride lowers PSA levels in men, certain factors increase testicular cancer risk, and current guidelines for penile cancer may lead to unnecessary surgeries.

This study found that Tripterygium wilfordii multiglycoside significantly inhibited testosterone-induced benign prostatic hyperplasia in rats without causing toxicity, suggesting its potential as a therapy for BPH.

PSA levels help determine prostate size and guide treatment choices for benign prostatic hyperplasia.

This study found that liarozole is more effective than cyproterone acetate for improving PSA response and survival in metastatic prostate cancer after first-line endocrine therapy, while maintaining quality of life.

This study found that the most likely cause of hypercalcemia in a patient with symptoms of hypervitaminosis A and a history of chronic vitamin A ingestion was vitamin A toxicity.

In this study, the researchers found that the picosecond pulsed alexandrite laser (PSAL) may be as effective and safe as the Q-switched alexandrite laser (QSAL) for treating freckles in Chinese patients.

This review found strong evidence supporting Finasteride's effectiveness in reducing symptoms and improving quality of life in patients with larger prostate volumes, earning it a grade A recommendation for clinical use.

In this study, the authors observed that treatment patterns for new benign prostatic hyperplasia largely aligned with guidelines, but 5-α reductase inhibitors were used inappropriately based on prostate size as indicated by prostate specific antigen.

This retrospective analysis reported significant increases in testosterone levels in men with testosterone deficiency using the Daily Subcutaneous Testosterone method combined with hCG and anastrozole, indicating its potential as a treatment option.

This study investigated the phytochemical composition and antibacterial and antioxidant activities of Zaleya pentandra extracts, finding high total polyphenol and flavonoid content and significant antibacterial effects, particularly in acetone extract, which may be suitable for developing antibacterial agents.

This study found that metformin is inversely associated with serum PSA levels in a dose-dependent manner, suggesting further research is needed on its potential impact on prostate cancer progression.

This study reports two cases where localized prostate cancer with low PSA levels was incidentally detected through CT scans performed for other medical reasons.

This analysis of the Prostate Cancer Prevention Trial found that finasteride reduces prostate cancer risk by nearly 25% and enhances the PSA test's ability to detect prostate cancer and high-risk diseases.

Combination therapy for BPH is cost-effective, especially for men with larger prostates.

This review evaluates the use of 5α-reductase inhibitors in feminising hormone therapy, finding their additive feminising benefits unclear due to their specific action on testosterone conversion, with concerns highlighted regarding limited supporting evidence and safety signals, particularly for psychiatric and sexual effects.

In this randomized trial of Iranian men with moderate to severe androgenetic alopecia, researchers found that both finasteride and dutasteride improved hair density over 24 weeks, with dutasteride showing stronger PSA reduction but similar safety to finasteride.

This review concluded that 5α-reductase inhibitors like finasteride and dutasteride offer limited additional feminising effects in hormone therapy for transfeminine individuals, with the clearest use being androgenetic alopecia treatment; more research is needed for other potential benefits.

This systematic review reported positive outcomes with gender-affirming hormone therapy in Canada and emphasized the urgent need for standardized outcome measurement tools to enhance evidence-based practices.

Hair loss can be an early sign of prostate enlargement.

In this study, dutasteride more effectively reduced prostate cancer cell viability than finasteride in vitro, but did not significantly alter the angiogenic response.

This study found that Lespedeza cuneata aqueous extract reduced serum dihydrotestosterone levels and 5α-reductase mRNA expression in testosterone-induced prostatic hyperplasia in rats, suggesting potential as a treatment for prostatic hyperplasia.

This study found that men with androgenetic alopecia had higher serum levels of testosterone and DHT compared to controls, suggesting a significant role of serum androgens in AGA development and progression.

In this study, Trapa bispinosa Roxb. pericarp extract demonstrated inhibitory effects on 5α-reductase activity both in vitro using LNCaP cells and in vivo in a mouse model of benign prostatic hyperplasia, suggesting its potential role in managing the condition.

In this study, short-term treatment with lovastatin showed no effect on symptom severity, prostate volume, or PSA levels in men with prostatic enlargement from presumed benign prostatic hyperplasia.

This study found that a hair lotion containing saw palmetto and 10% trichogen veg complex increased total hair count in male patients with androgenetic alopecia over four months, though observer assessments varied.

In this large British study, prostate cancer risk was linked to ethnicity, family history, prostate enlargement, and PSA testing, while excess adiposity, smoking, diabetes, and certain lifestyle factors were associated with a reduced risk.

This study found that total testosterone and free testosterone are recommended as first-line tests for diagnosing biochemical hyperandrogenism in women with PCOS; liquid chromatography with tandem mass spectrometry is preferred for its accuracy.