TLDR Metformin may lower PSA levels, possibly affecting prostate cancer development.
The study examined the impact of metformin on serum prostate-specific antigen (PSA) levels in 326 men with type 2 diabetes, revealing a significant inverse non-linear association between metformin dosage and PSA levels. Higher doses of metformin were linked to lower PSA levels, suggesting a potential influence on prostate biology and a possible reduction in prostate cancer risk. However, the study's cross-sectional design and limited demographic scope restricted causal conclusions, highlighting the need for further research in larger cohorts to confirm these findings and explore their implications for prostate cancer outcomes.
89 citations
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