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research Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer

30 citations , June 2010 in “Endocrine Related Cancer”

In this study, dutasteride more effectively reduced prostate cancer cell viability than finasteride in vitro, but did not significantly alter the angiogenic response.

research The Relationship Between Metformin and Serum Prostate‐Specific Antigen Levels

17 citations , July 2016 in “The Prostate”

This study found that metformin is inversely associated with serum PSA levels in a dose-dependent manner, suggesting further research is needed on its potential impact on prostate cancer progression.

research BIOLOGICAL ACTIVITY OF ANTIANDROGENS

51 citations , June 1970 in “British journal of dermatology/British journal of dermatology, Supplement”

This review discusses the biology of antiandrogens and highlights available bioassay models to predict their therapeutic effects on human skin, reporting no new clinical results.

research Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping

8 citations , June 2016 in “Clinical Chemistry”

This review discusses the expression of PSA in hormonally-regulated tissues and female malignancies, emphasizing its potential as a diagnostic biomarker and role in antidoping initiatives.

research Lower prostate cancer risk in Swedish men with the androgen receptor E213 A-allele

February 2017 in “Cancer Causes & Control”

In this study, Swedish men carrying the AR haplotype H2 were found to have a significantly lower risk of prostate cancer compared to those with the more common H1 variant.

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community Why hasn’t anyone made a "DHT sponge" biologic yet???

in Research/Science 45 upvotes 9 months ago

The conversation discusses the potential for developing a biologic "DHT sponge" to neutralize DHT in the bloodstream as a treatment for hair loss, suggesting it could be more targeted and have fewer side effects than current treatments like finasteride and dutasteride. Concerns include the complexity, cost, and potential side effects of such a treatment, as well as skepticism about its feasibility and market interest.

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

community Is this real chat? Finasteride -> fountain of youth and longevity drug?

559 upvotes 1 year ago

Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.

community Does a hair transplant last "forever"?

66 upvotes 1 month ago

Hair transplants are not permanent and require medication like finasteride or dutasteride to maintain results, as transplanted hair can still thin over time. Individuals with a history of prostate cancer may need to avoid these medications due to potential health risks.

community Dermarolling is a bit sad innit?

in Microneedling 232 upvotes 4 years ago

Hair loss treatments discussed include dermarolling, minoxidil, finasteride, and RU58841. Some users find dermarolling sad, while others mention the complexity of biological systems and limited research funding for hair loss.

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