TLDR Tripterygium wilfordii multiglycoside effectively reduced prostate enlargement in rats without harmful effects.
The study evaluated the effects of Tripterygium wilfordii multiglycoside (GTW) on testosterone-induced benign prostatic hyperplasia (BPH) in 45 rats divided into five groups. GTW was administered at doses of 10 and 20 mg/kg for 14 days. Results showed that GTW significantly reduced prostate weight, prostatic index, testosterone and dihydrotestosterone (DHT) levels in both serum and prostate, and serum prostate-specific antigen (PSA) levels compared to the BPH group. Histopathological examination confirmed that GTW inhibited prostatic hyperplasia without affecting liver and renal functions, suggesting GTW as a potential therapy for BPH.
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