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Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Researchers created a 3D hydrogel that mimics human hair follicles, which may help with hair loss treatments.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Topical minoxidil helps treat female pattern hair loss, but more research needed for other treatments.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Melatonin-loaded nanocarriers improve melatonin delivery and effectiveness for various medical treatments.

Different factors like pH, gel type, and chemical enhancers affect how well hydrocortisone gets into hair follicles, and less hydrated skin doesn't work well with the test method.

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

Women with hair loss had higher levels of certain hormones, suggesting a link to a condition like PCOS.

Keratinocytes help keep hair follicle cells and skin cells separate in 3D cultures, which is important for hair growth research.

Finasteride helps treat hair loss by blocking enzyme activity.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Two compounds from Asiasarum heterotropoides roots show potential as lung cancer treatments without harming normal cells.

The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Compounds from Alpinia zerumbet may help with hair regrowth and cancer treatment by targeting PAK1.

Researchers created a skin patch that delivers two drugs for treating enlarged prostate, which may improve patient use and dosage control.

Changing the 6-position on benzopyran molecules affects insulin release, with some compounds showing strong inhibitory effects.

Men with male-pattern baldness have higher levels of certain testosterone metabolites and may have more active androgen metabolism.

Softer hydrogel surfaces help maintain hair growth-related functions in skin cells.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

Removing a methyl group from the ITGAV gene speeds up bone formation in a specific type of bone disease model.

In 2017, a new method was created to efficiently produce a topical antiandrogen, a compound used to treat excess sebum and acne, with a high yield and purity.

Tridax procumbens plant parts boost immune response in mice.

Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

Analog 23 is a promising compound for prostate cancer treatment.