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Thymosin β4 and VEGF are important for organ function and may help with blood vessel formation.

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

Isotretinoin can cause serious birth defects and needs careful use, especially in pregnant women.

A 10-month-old boy with a rare combination of genetic conditions has severe immune deficiency and treatment challenges.

Intestinal intraepithelial lymphocytes are crucial for gut immunity and maintaining the mucosal barrier.

Netherton's syndrome is linked to high IgE levels and unique skin and hair symptoms, and may improve with ammonium lactate lotion and allergy management.

Mouse skin cancer progression involves a unique group of cells marked by ABCG2 and MTS24.

mEphA1 receptor tyrosine kinase is important for skin and hair development and may play a role in certain diseases.

Adults with Tatton-Brown-Rahman syndrome may have serious heart problems and need lifelong heart monitoring.

Mutations in the FOXN1 gene cause severe immune issues but don't affect hair and nails.

Hair follicles supply a crucial brain development protein to the brain via platelets.

Involucrin gene expression is controlled by specific proteins and signaling pathways.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Tyrosine kinases are important in skin autoimmune diseases and could be targets for new treatments.

A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.

A specific ATR gene mutation is linked to a hereditary oropharyngeal cancer syndrome.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

New genetic discoveries may lead to better treatments for alopecia areata.

RXRα is crucial for proper immune response and links diet to immune function.

RANKL causes lymph nodes to grow by making certain cells multiply.

Malt1 protease is essential for regulatory T cell function and could be targeted to boost antitumor immunity.

Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.

Nagashima-type palmoplantar keratosis in Asians is caused by a SERPINB7 gene mutation.

Acne is a temporary skin imbalance during puberty that often resolves on its own.

Men and women get COVID-19 at similar rates, but men tend to get sicker and have a higher risk of dying, while women usually have stronger immune responses and vaccine reactions.

Alopecia areata patients, especially women with nail issues or atopic diseases, are at higher risk for other autoimmune diseases.

Patients with RASopathies are at risk for autoimmune disorders and should be routinely screened.

Some patients developed hair loss after islet cell transplant possibly due to their immune-suppressing medications.

Myasthenia gravis can affect both motor and non-motor systems due to immune system issues.

MAIT cells may help fight COVID-19 but also contribute to severe inflammation.