Non-Motor Comorbidity of Myasthenia Gravis: Myasthenia Gravis as a Systemic Immunological Disorder Involving Non-Motor Systems

The document explored non-motor comorbidities of myasthenia gravis (MG) through two cases of thymoma-associated MG patients. Case 1 exhibited alopecia, pure red cell aplasia, and thymoma-associated multiorgan autoimmunity, while Case 2 showed alopecia, thrombocytopenia, hypogammaglobulinemia, and nephrotic syndrome. In both cases, autoreactive T lymphocytes stimulated by thymus tissue were implicated in the autoimmune symptoms. The study concluded that systemic immunological involvement due to thymoma-associated breakdown of immunoregulation in both motor and non-motor systems should be considered in MG patients.