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The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

Finasteride gel is slightly more effective than the tablet for treating hair loss.

Minoxidil and pyrithione zinc combo most effectively increases hair density.

Vitamin D receptor is crucial for starting hair growth after birth.

Hair follicles grow hair and release it through the skin.

Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.

Androstanediol glucuronide is a reliable marker for hirsutism in women.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

The most common hair loss type at specialist clinics is androgenetic alopecia, especially in younger men, followed by alopecia areata and telogen effluvium, with differences seen across regions.

Skin grafts are effective for chronic leg ulcers, especially autologous split-thickness grafts for venous ulcers, but more data is needed for diabetic ulcers.

Patients with Bohring-Opitz syndrome and ASXL1 mutations need regular kidney ultrasounds to check for tumors.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

Sostdc1 controls the size and number of hair and mammary gland structures.

MicroRNAs are crucial for controlling skin development and healing by regulating genes.

AGD1 is important for root hair development in Arabidopsis, working with phosphoinositide signaling and the actin cytoskeleton.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Different women's hair and skin glands respond to hormones in varied ways, which can cause unwanted hair growth even with normal hormone levels, and more research is needed to treat this effectively.

17β-estradiol can reduce inflammation in the skin.

Prolactin and melatonin can stimulate hair growth in Cashmere goat hair follicles, but melatonin may reduce follicle viability over time.

Vitamin D and its receptor may help prevent skin cancer.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Microneedles help improve drug delivery through the skin and are used in medicine and beauty treatments.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

Platelet-rich plasma, taken from a person's own blood, can help rejuvenate skin, stimulate hair growth, and treat hair loss, but more research is needed to confirm its safety and effectiveness.

The document describes a way to isolate and grow human hair follicle cells in 3D to help study hair growth.

Keratinocytes control how melanocytes work.

The L412F variant of TLR3 is linked to skin infections, more viral infections, and autoimmune issues.

Hair follicles in mutant mice self-organize into ordered patterns within a week.