119 citations
,
July 2016 in “Annals of the New York Academy of Sciences” This review examines the impact of vitamin D signaling in extraskeletal tissues and notes that expected benefits from animal and cell studies have not been consistently replicated in human clinical trials.
119 citations
,
January 2012 in “Nutrition & Metabolism” This article suggests that modern lifestyle changes, including diet, stress, and chronic anti-inflammatory medication use, may disrupt the natural process of inflammation resolution, increasing vulnerability to chronic disease.
119 citations
,
October 2011 in “Journal of Veterinary Internal Medicine” This review discusses the clinical manifestations and immune response to Rhodococcus equi infection in foals but reports no new clinical results.
115 citations
,
November 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review discusses the impact of sleep cycles and circadian rhythms on nighttime exacerbation of atopic dermatitis in children and presents potential treatment options for related sleep disturbances, but reports no new clinical results.
112 citations
,
May 2020 in “Nature Communications” This study found that cardiac fibroblasts significantly enhance the maturation of neonatal mouse and human embryonic stem cell-derived cardiomyocytes, suggesting a pivotal role in postnatal heart development and disease.
98 citations
,
December 2008 in “Journal of Investigative Dermatology” This review discusses the possible impacts of prolactin on skin conditions like psoriasis, alopecia, and stress-related dermatoses, emphasizing the need for further research to explore its therapeutic potential.
84 citations
,
March 2010 in “Infectious Disease Clinics of North America” The document concludes that rapid identification, isolation, and strict infection control are crucial to manage SARS outbreaks.
83 citations
,
June 2018 in “Frontiers in immunology” This review discusses the roles of αβ and γδ T cells in skin health and disease and reports no new clinical results; the authors highlight potential therapeutic developments.
75 citations
,
June 2019 in “International Journal of Molecular Sciences” This review discusses the therapeutic potential of costunolide for various diseases, highlighting its bioactivity and mechanisms, but it reports no new experimental results.
75 citations
,
August 2018 in “Biochemical pharmacology” This review discusses the potential of targeting the endocannabinoid system for treating skin disorders and reports no new clinical results, highlighting the need for further research.
75 citations
,
November 2016 in “Medicines” This review discusses the properties and therapeutic potentials of beta-sitosterol, highlighting a need for more detailed studies on its mechanisms and long-term effects in humans; it reports no new results.
72 citations
,
June 2013 in “Journal of feline medicine and surgery” This review discusses the infection dermatophytosis in cats and reports no new results; it emphasizes the difficulty of eradicating the disease in shelters and catteries.
70 citations
,
October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review discusses the JAK-STAT pathway and the use of FDA-approved JAK inhibitors for autoimmune and inflammatory diseases but reports no new research findings.
70 citations
,
January 2014 in “International review of cell and molecular biology” This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.
69 citations
,
January 2020 in “Veterinary World” This review examines factors influencing dermatophyte infection in companion animals, focusing on prevalence, clinical signs, pathogenesis, immune response, and the impact of cortisol and cytokines, but reports no new clinical results.
68 citations
,
May 2021 in “Endocrine” This review discusses the emerging "endocrine phenotype" of COVID-19, highlighting the implications for managing diabetes, obesity, vitamin D deficiency, and other endocrine conditions in affected patients.
68 citations
,
September 2018 in “International Journal of Molecular Sciences” In this study, researchers found that exposure to PM10 significantly increased inflammation and impaired collagen synthesis in human dermal fibroblasts, suggesting PM10 contributes to skin aging through these mechanisms.
68 citations
,
November 2015 in “The Journal of Allergy and Clinical Immunology” In this study, three patients with extensive alopecia areata showed varying degrees of hair regrowth after 20 weeks of treatment with ustekinumab, a cytokine-targeting therapy.
68 citations
,
November 2012 in “Journal of Investigative Dermatology” This study found that PGD2 inhibits hair follicle regeneration in mice through the Gpr44 receptor, suggesting that blocking PGD2 or Gpr44 may enhance skin regeneration after wounds.
67 citations
,
January 2022 in “Theranostics” This review highlights how advanced nanocarrier and microneedle-based transdermal drug delivery strategies can potentially improve the treatment of skin diseases by enhancing site-specific drug delivery, increasing skin penetration, and reducing systemic toxicity compared to conventional methods.
67 citations
,
February 2020 in “Journal of Ginseng Research” This review evaluates and classifies the non-saponin components of Korean Red Ginseng, emphasizing their combined role with saponins in the plant's bioactivity, but reports no new clinical results.
66 citations
,
March 2018 in “British journal of dermatology/British journal of dermatology, Supplement” This article reviews the role of perifollicular regulatory T cells in maintaining hair follicle integrity in the context of hidradenitis suppurativa and calls attention to inflammatory mechanisms without reporting new clinical results.
60 citations
,
September 2015 in “Expert Review of Clinical Immunology” This study suggests that CD8+ cytotoxic T lymphocytes play a crucial role in the development of alopecia areata, based on observations in rodent models that mimic human autoimmune disease.
60 citations
,
September 2013 in “Alimentary Pharmacology & Therapeutics” This review discusses the dermatological adverse events from immunosuppressive and anti-TNF therapy in IBD, finding increased risks of non-melanoma skin cancer and other skin conditions, and recommends regular cancer screening.
59 citations
,
October 2020 in “Stem Cell Reviews and Reports” This review discusses potential mechanisms contributing to higher COVID-19 mortality among men, particularly the roles of smoking, genetic factors, and reproductive hormones, without presenting new clinical findings.
58 citations
,
January 2006 in “Skin Pharmacology and Physiology” This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.
58 citations
,
January 2003 in “Thrombosis and Haemostasis” This review discusses how androgens may regulate wound healing and inflammation, noting that testosterone appears to inhibit healing and promote inflammation, but it reports no new clinical results.
56 citations
,
January 2021 in “Clinical and Experimental Medicine” This review highlights the challenges in treating alopecia areata, noting that current therapies often lead to relapse and have uncertain long-term effectiveness; it also points to potential future treatments such as JAK-STAT inhibitors and PRP.
53 citations
,
September 2020 in “Stem Cell Research & Therapy” This review discusses strategies to enhance mesenchymal stem cell therapy effectiveness but reports no new clinical results; it highlights the need for improved consistency and efficacy in MSC-based treatments.
51 citations
,
June 2021 in “Signal Transduction and Targeted Therapy” This review article summarizes recent strategies to enhance the precise control of CRISPR/Cas9 gene editing, addressing tissue-specific challenges and off-target effects by exploring various activation methods like cell-specific promoters and small molecules.