21 citations
,
April 1995 in “Mayo Clinic Proceedings” This case study describes a testosterone-secreting adrenal adenoma in a 55-year-old woman, highlighting the presence of Reinke's crystalloids, suggesting that Leydig cells may play a role in such tumors.
21 citations
,
December 2012 in “Maturitas” This study observed significant inter- and intra-individual variability in serum testosterone levels among women treated with subcutaneous testosterone implants, suggesting that therapy should be guided by clinical response rather than single serum measurements.
21 citations
,
January 2010 in “JOURNAL OF HEALTH SCIENCE” This study found that abietic acid from pine resin more effectively inhibits testosterone 5α-reductase than several plant extracts, suggesting potential for treating androgen-dependent diseases.
20 citations
,
April 2021 in “Journal of Womens Health” This guideline provides evidence-based recommendations for prescribing testosterone therapy to women with hypoactive sexual desire disorder, noting a moderate therapeutic benefit but highlighting limited data and regulatory challenges.
20 citations
,
June 2015 in “Hormone Molecular Biology and Clinical Investigation” This study found that long-term finasteride therapy in men with BPH worsened erectile dysfunction and reduced testosterone levels, while these effects were not observed with tamsulosin.
19 citations
,
October 2019 in “BMC Neuroscience” This study found weak to very weak correlations between estradiol, progesterone, and testosterone levels in the cerebrospinal fluid and serum of males without cerebral disorders.
19 citations
,
April 2019 in “Journal of Midwifery & Women's Health” This article reviews contraceptive options for individuals on testosterone gender-affirming hormone therapy, highlighting unique risks and benefits for this population, but it reports no new clinical findings.
19 citations
,
June 1997 in “The Journal of Clinical Endocrinology & Metabolism” This case study details a 57-year-old woman with symptoms of androgen excess, including rapid hair growth and temporal balding, alongside abnormal testosterone levels and a history of chronic renal failure.
19 citations
,
January 1997 in “Endocrinology” This study observed that testosterone inhibits hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps are present, with antiandrogen RU 58841 reversing this effect.
18 citations
,
October 2023 in “Nature Communications” In this study, male-pattern baldness was strongly associated with a higher risk of keratinocyte cancers, particularly squamous cell carcinoma and melanoma, likely due to increased sun exposure on the scalp rather than androgen levels.
18 citations
,
March 2020 in “Frontiers in Neuroendocrinology” This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.
18 citations
,
May 2014 in “Menopause” This study found that a 5-mg daily dose of transdermal testosterone cream in postmenopausal women restored testosterone levels to those typical of premenopausal women.
18 citations
,
September 1972 in “British Journal of Pharmacology” In this study on male rats, parachlorophenylalanine treatment induced hypersexual behavior and hair loss linked to increased social interaction but had no effect on brain serotonin when testosterone was used instead.
17 citations
,
March 2016 in “Liver international” This study found that low serum testosterone and elevated serum oestrone in men with cirrhosis are associated with worse liver disease and adverse health outcomes, suggesting oestrone as a potential ill health marker.
17 citations
,
April 2009 in “Andrologia” This case study reports that hormonal imbalances in a young boy with precocious pseudopuberty returned to normal after the removal of a testicular interstitial cell tumor, with normal spontaneous puberty following.
17 citations
,
July 2003 in “Metabolism-clinical and Experimental” This study found that young women with female-pattern hair loss exhibit increased testosterone production rates while dihydrotestosterone production rates remain within or below the normal range.
17 citations
,
March 2020 in “Frontiers in Chemistry” This study isolated new geranylated coumarins from Mammea siamensis flowers and found that several of these compounds inhibit testosterone 5α-reductase.
17 citations
,
February 2019 in “Journal of Clinical Medicine” This article reviews guidelines for testosterone replacement therapy in late-onset hypogonadism, emphasizing the need for clear indications and appropriate testing before treatment, but provides no new research findings.
16 citations
,
August 2007 in “Histopathology” This case report describes a functional adrenocortical oncocytoma that co-secreted testosterone and cortisol.
16 citations
,
September 1964 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that new compounds with anti-androgenic effects were found to counteract testosterone in animals without significant estrogenic activity, indicating potential for managing androgen-related conditions.
16 citations
,
June 2022 in “Transgender Health” This review suggests that oocyte retrieval may be viable for transgender men on testosterone therapy, with potentially manageable effects on fertility preservation without requiring extensive hormone suspension.
16 citations
,
January 2019 in “Pharmaceutical biology” This study found that Lespedeza cuneata aqueous extract reduced serum dihydrotestosterone levels and 5α-reductase mRNA expression in testosterone-induced prostatic hyperplasia in rats, suggesting potential as a treatment for prostatic hyperplasia.
15 citations
,
October 2011 in “Gynecological Endocrinology” This study found that obesity in PCOS women with biochemical hyperandrogenemia lowers androstenedione levels and increases the testosterone to androstenedione ratio, but this was not observed in women with clinical hyperandrogenemia or in controls.
15 citations
,
November 1983 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that testosterone propionate increased hair mass in female hamsters' flank organs, while cyproterone acetate applied topically reduced androgen-stimulated hair in a dose-dependent manner.
14 citations
,
September 2017 in “General and comparative endocrinology” In this study, researchers observed that in barn owls, the relationship between black feather spot size and testosterone levels varied by age and sex, suggesting involvement of genes regulating both traits rather than direct influence of testosterone on feather coloration.
14 citations
,
July 2011 in “Experimental Dermatology” In this study, topical EGCG significantly reduced testosterone-induced hair loss and follicular apoptosis in mice, without altering testosterone or dihydrotestosterone concentrations.
14 citations
,
December 1998 in “The Journal of Clinical Endocrinology and Metabolism” This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.
14 citations
,
November 1982 in “British Journal of Dermatology” This article discusses whether testosterone's metabolism to 5α-dihydrotestosterone is necessary for androgenic effects in the skin but reports no new experimental results.
13 citations
,
January 2014 in “PubMed” In this study, A. capillus-veneris solution demonstrated potential to reduce hair loss and improve hair characteristics in a testosterone-induced alopecia mouse model.
12 citations
,
December 2020 in “Comprehensive psychoneuroendocrinology” This study found that progesterone levels were higher and increased significantly throughout pregnancy, contrasting with stable levels in non-pregnant women.