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The document concludes that early diagnosis and treatment of PCOS in teenagers is important for managing symptoms and preventing long-term health problems.

Men with early balding often have hormone levels similar to women with polycystic ovary syndrome.

Men who start puberty later may have lower sperm quality and different hormone levels in adulthood.

Losing weight and taking birth control pills can greatly improve severe male hormone excess in women with PCOS.

Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

Skin problems like acne, excessive hair growth, and oily skin are common in women with PCOS and can help with early diagnosis.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Using anabolic-androgenic steroids can harm men's reproductive health and increase the risk of heart problems and death.

Most insurance companies do not cover extra gender-affirming surgeries, with coverage being low and inconsistent.

Hair follicles significantly affect the skin absorption of some drugs.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Extracts from Alnus sibirica and oregonin may help with hair growth and prevent hair loss.

Phyllanthus niruri extract may help treat hair loss by promoting hair growth and blocking a hair loss-related enzyme.

Guava leaf extract may help treat hair loss and protect cells by blocking certain genes and fighting damaging molecules.

Jagged1 and Epidermal Growth Factor together significantly increased hair growth in mice with androgen-suppressed hair.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Metformin is less effective in men with early-onset hair loss.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Facial hair is crucial for transgender men's gender identity and transition.

Oxidative stress and immune dysfunction are linked to both Hashimoto's thyroiditis and polycystic ovary syndrome, with diet and specific treatments important for managing these conditions.

Early hormones shape sex-specific differences in rat glands.

Polycystic Ovary Syndrome (PCOS) is common in infertile women and obese women with PCOS have more severe ovulatory problems, needing more care.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.