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The document concludes that understanding hair biology is key to treating hair disorders, with gene therapy showing potential as a future treatment.

Regulatory T cells protect hair follicle stem cells by maintaining immune privilege in the skin.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The HoxC gene cluster and its enhancers are essential for developing hair and nails in mammals.

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

The gene Ascl4 is not necessary for the development of hair, teeth, or mammary glands.

Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

Ionizing radiation causes irreversible skin damage, with single doses leading to acute injury and hair graying, and fractional doses causing more severe long-term tissue damage.

Norepinephrine helps skin cells grow, which is important for hair growth.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

Blocking Janus kinase 1 helps stop inflammation and regrow hair, making it a good treatment for hair loss from alopecia areata.

Metformin, usually used for diabetes, can also help treat hair loss from alopecia areata due to its ability to reduce inflammation and stimulate new hair growth.

Sox9 is present in most canine skin tumors and may help understand stem cells' role in these cancers.

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

Cow milk sugars increase fat production and inflammation in skin oil cells.

BRL 7660, once studied for male contraception, showed promise as an acne treatment but was not developed further due to competing drugs.

Ectodysplasin inhibits Wnt signaling to help form hair follicles.

Mice genetically modified to produce more CD109 in their skin had less inflammation and better healing with less scarring.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.

Aquaporins could be new drug targets for treating polycystic ovary syndrome.

Sirtuin 1 could be a potential drug target for treating hypertrophic scars.

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

The fascial layer is a promising new target for wound healing treatments using biomaterials.