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Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.

This study found that neuroactive steroids like DHEA and pregnenolone influence cocaine-induced appetence in mice through their interaction with the ς₁ receptor, suggesting a role in individual vulnerability to addiction.

This study found that secretory proteins in DFCM play crucial roles in regulating nerve restoration by forming significant protein interaction networks during the wound repair process.

In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.

This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.

This study developed a novel mouse model of catamenial epilepsy by manipulating neurosteroid levels and demonstrated that withdrawal increases seizure susceptibility, potentially linked to changes in GABAA receptor-subunit plasticity.

In this study, researchers observed that P2X3-immunoreactive fibers extensively innervate the epidermis of rats, suggesting a primary role in detecting noxious stimuli in cutaneous tissue.

This review evaluates controlled studies on Platelet-Rich Plasma for androgenetic alopecia treatment, reporting positive effects on hair growth and density but highlighting the need for standardized protocols.

This study identified a subtype of itch-sensing neurons in mice, which express Ret and somatostatin, and found that their ablation reduces scratching induced by certain pruritogens.

In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, with both epithelial and neural components exhibiting dynamic remodeling, highlighting intricate epithelial-neural interactions in maintaining homeostasis.

This study concluded that the increase in NGF mRNA levels during mouse whisker pad development is influenced by soluble factors produced within the tissue, rather than linked to epidermal differentiation.

This review reports on the potential of non-viral and stimuli-responsive systems to improve CRISPR-Cas9 delivery for gene-editing therapies, highlighting recent progress with systems like lipid-based nanoparticles that enhance targeting specificity and stability.

In this study, researchers found that the bioactive lipid sphingosine 1-phosphate and its receptor, S1PR3, are essential for regulating mechanical pain sensitivity in mice.

In this study, researchers found that during late pregnancy, neuroactive steroid fluctuations increase the number of extrasynaptic GABAA receptors in rat hippocampal cells.

This article discusses the role of epimorphin as a key morphoregulator for various epithelial cells in tubulogenesis and reports no experimental results on its signaling pathways.

This study found that melatonin-loaded nanoparticles improved antidepressant effects and HPA axis regulation in pinealectomized rats, compared to free melatonin, through controlled-release properties.

RY-023, a specific drug, can improve early stage memory learning without affecting general activity in rats, but it's less effective for later learning stages and doesn't impact memory recall.

This study found that stress increases the number of peptidergic nerve fibers and mast cell activity in mouse skin, suggesting a significant neuro-immune interaction under stress.

This study found that somatosensory axons innervating Merkel cells in adult mouse skin exhibit significant plasticity, influenced by epithelial and neural factors, indicating a complex interaction in maintaining homeostasis.

This study found that changes in the brain concentrations of neuroactive steroids during pregnancy are linked to increased Y 1 receptor gene expression in the medial amygdala of transgenic mice.

In this study, researchers developed a new method for producing dissolving microneedle array patches containing mesoporous silica nanoparticles, successfully confirming nanoparticle deposition and release in both ex vivo and in vivo models.

Neurosteroids may help prevent seizures in epilepsy.

This study reports that oxytocin receptor expression in keratinocytes shows a potential relationship with touch sensory neurons, suggesting a role in skin sensitivity and the broader function of sensory neurons.

This review discusses recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlighting their design rationales and potential biomedical applications, but reports no new experimental results.

This thesis developed stimuli-responsive nanocarriers, demonstrating their potential for targeted genetic material delivery with reduced toxicity and diagnostic applications, and explored pH-sensitive nanogels for effective skin drug delivery and monitoring.

This study developed the CATNIP computational model, which uses biological and chemical information to successfully identify drug repurposing opportunities for various conditions, including Parkinson’s disease and Type 2 Diabetes.