November 2024 in “Human Cell” This study found that treating rat whisker follicle stem cells with retinoic acid and epidermal growth factor induced them to express synaptophysin, a marker of mature neurons, although there was a reduction in other neural markers, suggesting potential for neuro-regeneration applications.
April 2023 in “Journal of clinical and translational science”
In this study, highly dynamic remodeling was observed in mouse somatosensory axons and Merkel cells, indicating that epithelial-neural interactions help maintain homeostatic remodeling, with additional intrinsic neural mechanisms contributing to axonal plasticity.
October 2014 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” This study identified a new subset of Ret-positive sensory neurons involved in itch perception, characterized by their unique expression profile and response to specific itch-inducing molecules.
34 citations
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July 2006 in “The Journal of Comparative Neurology” This study found that overexpression of neurotrophin 4 in mouse skin increased hair follicle and Meissner corpuscle innervation without altering sensory neuron numbers, differing from brain-derived neurotrophic factor by not affecting Merkel cell numbers.
November 2025 in “Stem Cell Reviews and Reports” The error in figures didn't affect the study's results or conclusions.
122 citations
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June 1998 in “PubMed” This study found that sensory and sympathetic innervation in the mystacial pads of mice is governed by a balance of neurotrophin signaling, highlighting the roles of NGF/trkA and NT-3/trkC pathways.
66 citations
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July 2007 in “Journal of Molecular Medicine” This study in mice demonstrated that stress or nerve growth factor injection increases sensory neuron activity related to skin innervation, suggesting a strong connection between stress perception and neurogenic skin inflammation.
34 citations
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November 1991 in “Choice Reviews Online” This work reviews the structure and functions of the nervous system, covering topics from nerve cell properties to the mechanisms of learning and memory, but does not present new research findings.
October 2023 in “IBRO neuroscience reports” Rat hair follicle stem cells have functional oxytocin receptors, useful for studying neuropsychiatric disorders.
June 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found a specific T cell receptor that may be key in carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis, suggesting potential therapeutic targets.
January 2022 in “Social Science Research Network” This study found that most potassium channel blockers increased the activity of slowly adapting mechanoreceptors in rat whisker pads, while the opener NS1619 decreased their evoked activity.
109 citations
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November 2011 in “Nature Neuroscience” 104 citations
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December 2004 in “Journal of Neurochemistry” This study found that androgens, specifically DHT, induced neurite outgrowth in motor neurons by up-regulating the neuritin protein, with testosterone being less effective.
109 citations
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April 1997 in “Archives of Dermatological Research” The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.
This study in adult mice found that somatosensory axons innervating Merkel cells in the skin are highly plastic, with significant remodeling in response to epithelial turnover, and that Merkel cells play a role in limiting axonal branching and promoting their maturation.
This study observed a high degree of plasticity in somatosensory axons innervating Merkel cells in mouse skin, finding that both axons and Merkel cells underwent dynamic remodeling, with their interactions influencing axonal branching and maturation.
September 2002 in “Epiliepsy currents/Epilepsy currents” This study found that deoxycorticosterone-derived neurosteroids modulate GABA A receptor function and may influence stress-induced changes in seizure susceptibility by elevating seizure thresholds in animal models.
December 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” The KDM1 gene helps Venus flytraps close by managing potassium ions.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that in live rodents, actin filaments adjust their structure to facilitate membrane transfer between cellular compartments; linear filaments stabilize fused membranes, while branched filaments, connected by the protein Ezrin, drive integration, demonstrating actin's role in adapting to membrane biophysical changes.
This review discusses the role of neuroactive steroids in physiological processes and their potential involvement in neuropsychiatric disorders, but it reports no new experimental findings.
In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, revealing that both epithelial-neural crosstalk and intrinsic neural mechanisms contribute to axonal patterning and remodeling during epithelial homeostasis.
May 2026 in “Journal of Controlled Release”
5 citations
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September 2022 in “Molecular pharmacology” This article reviews current knowledge on KATP channel drug binding modes through cryogenic electron microscopy, highlighting distinct binding sites in the sulfonylurea receptor and potential mechanisms of drug action, but reports no new experimental results.
1 citations
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January 2018 This study found that sphingosine 1-phosphate and its receptor S1PR3 are essential in regulating the acute mechanical pain response, highlighting their role in mechanonociception without affecting responses to innocuous touch or thermal stimuli.
February 2026 in “Advanced Science” This study found that the combination of TTNPB and CHIR99021 enhanced the derivation of highly advanced neural stem cells from human pluripotent stem cells, with improved chromatin accessibility and neuroectodermal gene expression, and these cells successfully engrafted in rat hippocampi to ameliorate depression-like symptoms.
36 citations
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March 2005 in “Biotechnology and Bioengineering” This study demonstrated that a novel synthetic amyloid template accelerates the deposition of insulin monomers into amyloid fibrils without a lag time, potentially aiding in vitro screening of amyloid deposition inhibitors.
24 citations
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April 2022 in “International Journal of Molecular Sciences” This study found that TRPV4 activation induced massive exocytosis and cellular changes associated with ferroptosis in melanoma cells, highlighting a potential role for TRPV4 in mediating these processes.
49 citations
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March 1996 in “Experimental Brain Research”
This study observed that Merkel cells and their associated somatosensory axons in mouse skin exhibit significant plasticity, remodeling dynamically to maintain homeostasis. Axonal branching patterns were notably influenced by Merkel cells, suggesting epithelial-neural interactions play a key role in axonal plasticity and patterning.