TLDR Different rat and mouse strains respond differently to stress and alcohol, which may help us understand similar human mechanisms.
The document discussed how neuroactive steroids, which are steroids that quickly change neuronal excitability through membrane receptors like GABAA receptors, played a role in regulating various physiological processes such as the HPA axis function, ovarian cycle, pregnancy, aging, and reward. It highlighted that changes in the synthesis of these steroids were linked to several neuropsychiatric disorders. The study focused on the different responses to stress and ethanol in rat and mouse strains, suggesting that these findings could be relevant for understanding similar mechanisms in humans.
January 2017 in “Elsevier eBooks” Stress and hormones like progesterone can affect absence seizures, but their effects change with different life stages.
18 citations
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September 2021 in “Journal of Neuroendocrinology” Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.
34 citations
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April 2014 in “Psychopharmacology” Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.
248 citations
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December 2011 in “Journal of Neuroscience” Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.
123 citations
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December 2015 in “Journal of Neuroendocrinology” New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.
18 citations
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March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.