Androgen-Induced Neurite Outgrowth Is Mediated By Neuritin In Motor Neurons

    December 2004 in “ Journal of Neurochemistry ”
    Thomas U. Marron, Vittoria Guerini, P. Rusmini, D. Sau, Tiziana A. L. Brevini, L. Martini, Angelo Poletti
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    Studysummary This study found that androgens, specifically DHT, induced neurite outgrowth in motor neurons by up-regulating the neuritin protein, with testosterone being less effective.
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    The study investigated the role of androgens in neurite outgrowth in motor neurons, focusing on the protein neuritin. Researchers used a model of immortalized motor neuronal cells expressing the mouse androgen receptor (mAR) to analyze androgen effects. They found that androgens, particularly 5α-dihydrotestosterone (DHT), up-regulated the neuritin gene, promoting neurite elongation. This effect was counteracted by the anti-androgen Casodex and the 5α-reductase type 2 enzyme inhibitor finasteride. Silencing neuritin with siRNA abolished the androgenic effect on neurite outgrowth, suggesting that androgens promote motor neuron development and regeneration through neuritin regulation.
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