Spatial and Temporal Coordination of Force-Generating Actin-Based Modules Drives Membrane Remodeling In Vivo

    December 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Marco Heydecker, Akiko Shitara, Desu Chen, Duy Tran, Andrius Masedunskas, Muhibullah S. Tora, Seham Ebrahim, Mark A. Appaduray, Jorge Luis Galeano Niño, Abhishek Bhardwaj, Kedar Narayan, Edna C. Hardeman, Peter W. Gunning, Roberto Weigert
    TLDR Actin filaments help stabilize and integrate cell membranes during transfer.
    The study investigates how actin filaments adjust their structure to facilitate membrane transfer between cellular compartments with different compositions and properties. Using live rodent models and intravital subcellular microscopy, the researchers found that linear actin filaments form a lattice that stabilizes granule membranes post-fusion with the plasma membrane. Additionally, branched actin filaments, connected to membranes by the protein Ezrin, initiate and complete the integration process. This research underscores the adaptability of the actin cytoskeleton in response to changes in membrane biophysical properties.
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