Neurotransmitter Signaling Specifies Sweat Gland Stem Cell Fate Through Intracellular Calcium Regulation

April 2023 in “ Journal of Investigative Dermatology ”

C. Lu

Platelet-Rich Plasma Androgenetic Alopecia hair growth hair density hair diameter PRP AGA

TLDR PRP can improve hair growth in people with hair loss, but more research is needed.

This study reveals that neurotransmitters from sympathetic nerves play a crucial role in sweat gland development by regulating intracellular calcium levels. Initially, norepinephrine promotes sweat duct elongation, followed by acetylcholine, which specifies sweat gland stem cell fate. The absence of neuronal signals causes basal cells to adopt luminal cell characteristics. Sarcolipin (SLN) is down-regulated in myoepithelial cells upon denervation, leading to decreased intracellular calcium and increased luminal features. Contrary to previous beliefs, high calcium levels are necessary for myoepithelial cell specification, while lower levels promote luminal cell fate. This research underscores the long-term impact of neuronal signals on glandular stem cell specification.

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