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The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Low SULT activity in hair follicles leads to better response to oral minoxidil for hair loss.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.

Daily low-dose aspirin lowers minoxidil's effectiveness for hair loss treatment.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Bariatric surgery improves skin conditions and metabolism but may cause nutritional deficiencies and hair loss.

Molybdenum nanoparticles could be a new treatment for hair loss, working differently than minoxidil.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

The document concludes that treatments for female hair loss and excessive hair growth are temporary and not well-studied.

Male-pattern baldness might be caused by the effect of hormones on scalp blood vessels.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Phosphatidic acid may help hair grow by affecting cell growth pathways.

Hair proteins have weak spots in their α-helical segments.

Researchers created a mouse model of a type of rickets that does not cause hair loss.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.