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The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Low SULT activity in hair follicles leads to better response to oral minoxidil for hair loss.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

Phosphatidic acid may help hair grow by affecting cell growth pathways.

Daily low-dose aspirin lowers minoxidil's effectiveness for hair loss treatment.

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Bariatric surgery improves skin conditions and metabolism but may cause nutritional deficiencies and hair loss.

Molybdenum nanoparticles could be a new treatment for hair loss, working differently than minoxidil.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

Male-pattern baldness might be caused by the effect of hormones on scalp blood vessels.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Best hair growth results from combining finasteride and minoxidil.

Apoptosis is crucial for healthy skin and treating skin diseases.

The document concludes that treatments for female hair loss and excessive hair growth are temporary and not well-studied.

The conclusion is that treatments like finasteride and minoxidil can prevent baldness progression and improve hair density, but more research is needed on other therapies.

Orobanche rapum extract rejuvenates skin and protects skin bacteria, leading to healthier skin.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

The paper suggests that hair loss might be caused by skull growth, not just DHT's effect on hair follicles, and calls for more research.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

The article concludes that schoolchildren and adolescents experienced various skin issues during the COVID-19 pandemic, including acne from masks and other skin reactions from the virus and vaccines.