research Influence of substance-P on cultured sebocytes
This study found that substance P may be involved in the pathogenesis of acne by increasing the expression of certain cytokines and receptors in cultured sebocytes.
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30 / 1000+ results research Substance P in keratosis follicularis spinulosa decalvans
This article reviews the characteristics and inheritance patterns of keratosis follicularis spinulosa decalvans, but it does not present new clinical findings, noting the disease's complex and poorly understood pathogenesis.
research Effects of Guasha on histomorphology of scraped skins and on expression of calcitonin gene-related peptide and substance P in rats
This study found that Guasha therapy did not significantly alter nerve fiber morphology or the expression of CGRP and SP in rat skin, with parameters generally returning to normal within five days.
research Effects of Substance P on the Expression of Various Factors to control Hair Growth in Human Hair Follicle Culture
This study found that while SP did not enhance linear hair growth in cultured hair follicles, it prolonged the anagen phase and altered the expression of growth factors and apoptosis-related molecules, suggesting a stimulatory effect on hair growth.
research Stress Inhibits Hair Growth in Mice by Induction of Premature Catagen Development and Deleterious Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways
This study found that psychoemotional stress disrupts hair growth in mice by terminating anagen and suggests a potential pathway for pharmacological management of stress-related hair loss in humans.
research Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P
This study demonstrated that stress inhibited hair growth in mice, likely through substance P-dependent activation of immune cells, highlighting a brain-hair follicle connection.
research Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice
The researchers reported that reactive oxygen species regulate the stress-induced SP-Mast cell pathway, which might support using antioxidants to treat stress-related hair loss.
research Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin
This study identifies substance P, TNFα, and IFNγ as novel regulators of prolactin and its receptor expression in human skin, suggesting intracutaneous prolactin is not controlled by dopamine.
research New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP3‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75NTRand TrkA) inex vivohuman male androgenetic scalp hair follicles
In this study, researchers found that caffeine can counteract stress-induced damage in ex vivo human androgenetic alopecia hair follicles, suggesting it may help prevent stress-related hair loss.
research Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle
This study found that activating the Nrf2 pathway in human mast cells effectively suppresses degranulation and inflammation induced by substance P.
research Substance P prolongs human hair growth in vitro
This study investigated the effects of substance P on human hair growth but found its role in hair follicle physiology remains unclear.
research Reduced rates of substance use disorder in patients with alopecia: An all of us case-control study
This study found that alopecia may be a potential protective factor against substance use disorder, with a decreased odds of 0.73, possibly due to fears of exacerbating hair loss or increased mental health support.
research Cutaneous manifestations associated with substance use disorders
This review provides an overview of skin manifestations associated with substance use disorder but reports no new clinical findings; the authors emphasize the importance of dermatological evaluation and multidisciplinary care in managing these cases.
research Tissue and serum levels of substance P in trichodynia of androgenetic alopecia patients
This study found that patients with trichodynia associated with androgenetic alopecia had significantly higher levels of substance P in both tissue and serum compared to healthy controls, suggesting a potential role for this neurotransmitter in the condition's pathogenesis.
research Associations of prenatal and postnatal exposure to perfluoroalkyl substances with pubertal development and reproductive hormones in females and males: The HOME study
This study observed that higher PFAS concentrations during adolescence were linked to later pubertal development and lower estradiol levels in females, but not in males, potentially due to PFAS excretion with menstrual fluid.
research Substances declared as active ingredients in topical anti-hair loss products – a review of the evidence for their effectiveness in light of clinical studies
The effectiveness of ingredients in anti-hair loss products varies, and clinical trials are crucial to determine their success.
research Evaluation of serum substance P,folic acid and ferritin in female patients with hair fall and trichodynia
In this study, the researchers aimed to evaluate the levels of substance P, folic acid, and ferritin in the serum of female patients experiencing hair fall and trichodynia.
research 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation
Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.
research LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis
This study found that Substance P increased mitochondrial activity and biogenesis markers in cultured human scalp hair follicles, suggesting a novel link between stress-related neuropeptide signaling and hair follicle mitochondrial responses.
research A Fast and Efficient UPLC-ESI-MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss
This study presents a new method using UPLC-ESI-MS/MS for analyzing the constituents of a medicinal herbal complex extract, which includes herbs traditionally used to prevent hair loss and promote hair growth; no clinical results were reported.
research Bioactive Substances Derived From Probiotic Lactobacillus acidophilus Reduce Motility And Viability In Cervical Cancer Cells
This study found that Lactobacillus acidophilus cell-free supernatant caused significant cytotoxicity, reduced migratory ability, and induced apoptosis in cervical cancer cell lines, suggesting its potential as a non-toxic adjunct therapy for cervical cancer.
research Effet de la consommation de régimes carencés en iode ou contenant de substances goitrigènes ou supposées sur la croissance pondérale de rats Wistar
This study found that iodine deficiency, iodine excess, or the presence of antithyroid substances affected growth and behavior in Wistar rats, leading to various symptoms such as lethargy and alopecia.
research Oral intake of anti-hangover substance increases aldehyde dehydrogenase activity: New preventive and therapeutic potentials for oxidative neuronal injury?
The anti-hangover product may boost enzyme activity to help prevent brain damage.
research BIOACTIVE SUBSTANCE OF MEDICINAL PLANTS EFFECTIVE AGAINST HAIR LOSS
This review article discusses the potential benefits of phytochemicals in hair care, highlighting their ability to improve scalp health, reduce dandruff, and promote hair growth, while emphasizing their safety and minimal side effects compared to conventional therapies.
research The synergistic effect of phototherapy and active substances on hair growth
In this study, the combination of low level light therapy with arginine, arterial extract, or biotin tripeptide-1 was associated with improvements in hair density and follicle structure in androgenic alopecia.
research Machine Learning-Driven Optimization of Therapeutic Substance Composition for High-Hardness, Fast-Dissolving Microneedles for Androgenetic Alopecia Treatment.
This study found that a machine-learning-driven strategy helped develop microneedles with high hardness and rapid dissolution, effectively promoting hair regrowth in androgenetic alopecia mice by activating the Wnt/β-catenin pathway, surpassing minoxidil's effects without biosafety risks.
research Extractable substances from human hair: a discussion about the origin of the holes
This study describes the presence of holes in hair fibers, absent in hair follicles, likely forming from daily care actions and removal of extractable substances.
research Severe Lichen Planus Pigmentosus Inversus in an Elderly Female Following Intra-Articular Injections of Homeopathic Substances
In this case study, an 80-year-old woman developed lichen planus pigmentosus inversus after receiving multiple intra-articular injections of a homeopathic preparation, suggesting a possible link, though causality remains speculative.
research Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp
This article reviews various types of alopecia, their diagnostic features, and patterns, but presents no new clinical findings; the authors discuss multiple mechanisms and classification challenges.
research Prenatal and prepubertal exposures to organochlorine compounds and perfluoroalkyl substances and pubertal development at age 12: The PELAGIE cohort study
This study reports that prenatal and prepubertal exposure to organochlorine compounds and perfluoroalkyl substances may affect pubertal development at age 12, with observed changes in development patterns in both girls and boys, highlighting the need for further research.