Comparative Efficacy of Transdermal Forms for Alopecia Therapy

December 2021 in “ Razrabotka i registraciâ lekarstvennyh sredstv ”

U. V. Nogaeva, D. Yu. Ivkin, Г. А. Плиско, E. V. Flisyuk, V. E. Kovanskov, Yu. G. Shtyrlin, К. О. Сидоров

transdermal forms alopecia therapy substance Y gel alcohol oil minoxidil burdock oil hair follicles growth phase 2% minoxidil solution topical alopecia therapy Rogaine

TLDR The gel form of substance Y is the most effective for treating hair loss.

The study investigated the efficacy of a new substance Y in various transdermal forms (gel, alcohol, and oil) for treating alopecia, compared to minoxidil and burdock oil, using male C57BL/6 mice. Results showed that the gel form of substance Y was the most effective, leading to a higher number of hair follicles in the growth phase than the 2% minoxidil solution, with statistically significant differences. However, substance Y did not exhibit antioxidant activity. The findings suggest that the gel form of substance Y is promising for topical alopecia therapy, with plans for further mechanism studies and patent registration.

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