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      Tracing the Cellular Origin of Cancer

      research Tracing the Cellular Origin of Cancer

      232 citations, January 2013 in “Nature Cell Biology”
      Understanding where cancer cells come from helps create better prevention and treatment methods.
      Eph Receptors and Ephrins: Therapeutic Opportunities

      research Eph Receptors and Ephrins: Therapeutic Opportunities

      222 citations, October 2014 in “Annual Review of Pharmacology and Toxicology”
      Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

      research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

      220 citations, June 2013 in “The Journal of Pathology”
      The study on lichen planopilaris (LPP) involved 42 adult patients and demonstrated that the disease was characterized by the collapse of immune privilege in the hair follicle's epithelial stem cell niche, specifically in the bulge area. This collapse was marked by increased expression of MHC class I and II molecules and a reduction in TGFβ2 and CD200 expression, leading to a Th1-biased cytotoxic T cell response. The findings suggested that interferon-γ (IFNγ) played a significant role in this process, indicating that LPP might be an autoimmune disease. The study proposed that protecting or restoring immune privilege in the bulge could be a therapeutic strategy for managing this form of cicatricial alopecia.

      research Epigenetics of Colorectal Cancer

      218 citations, September 2012 in “Gastroenterology”
      Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.

      research Hedgehog Signaling in Skin Development and Cancer

      190 citations, July 2006 in “Experimental Dermatology”
      The document reviewed the role of the hedgehog (Hh) signalling pathway in skin development and cancer, particularly basal cell carcinoma (BCC), which affected 750,000 Americans annually. It highlighted how mutations in genes like PATCHED (PTCH), sonic hedgehog (Shh), and smoothened (Smo) expanded the understanding of BCC's genetic basis. The Shh pathway was crucial for stem cell maintenance and hair follicle and sebaceous gland development in the skin, though it played a minimal role in adult tissues. The review summarized studies on the Shh pathway's involvement in skin development and cancer, described animal models based on this pathway, and discussed chemoprevention strategies for BCCs, providing insights into molecular target-based prevention and treatment of skin cancer.
      The PDGF/PDGFR Pathway as a Drug Target

      research The PDGF/PDGFR Pathway as a Drug Target

      182 citations, November 2017 in “Molecular Aspects of Medicine”
      The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

      research Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression

      176 citations, February 2006 in “Cancer Research”
      The study demonstrated that the loss of Patched 1 (Ptch1) function in the basal cell population of mouse skin was sufficient to induce rapid skin tumor formation, similar to human basal cell carcinoma (BCC). The research showed that Ptch1 did not affect the nuclear translocation of β-catenin or activate the Notch pathway, but its absence led to the nuclear accumulation of cell cycle regulators cyclin D1 and B1. This suggested that Ptch1 acted as a tumor suppressor by inhibiting cell cycle progression at the G1-S and G2-M phases, functioning as a "gatekeeper." The mouse model used in this study, due to its high frequency and rapid onset of tumors, was considered ideal for testing therapeutic strategies, including Patched pathway inhibitors.
      Hair Follicle Stem Cells: Walking the Maze

      research Hair Follicle Stem Cells: Walking the Maze

      165 citations, June 2007 in “European Journal of Cell Biology”
      Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

      research Quality of Life in Cutaneous Lupus Erythematosus

      158 citations, March 2011 in “Journal of the American Academy of Dermatology”
      Patients with cutaneous lupus erythematosus have a severely impaired quality of life, especially emotionally.
      Molecular Mechanisms of Viral Oncogenesis in Humans

      research Molecular Mechanisms of Viral Oncogenesis in Humans

      141 citations, August 2018 in “Nature Reviews Microbiology”
      Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.
      Dermatological Adverse Events with Taxane Chemotherapy

      research Dermatological Adverse Events with Taxane Chemotherapy

      141 citations, September 2016 in “European Journal of Dermatology”
      Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.

      research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

      140 citations, February 2014 in “Neuron”
      The study revealed that the opioid system, particularly through delta opioid receptors (DOR), played a significant role in regulating cutaneous mechanosensation, including both touch and pain. DORs were found on myelinated mechanoreceptors associated with structures like Meissner corpuscles and Merkel cell-neurite complexes. These receptors also appeared on a subset of nociceptors coexpressing mu and delta opioid receptors. Activation of DORs at the central terminals of these mechanoreceptors inhibited synaptic input to the spinal dorsal horn by blocking voltage-gated calcium channels. This mechanism suggested that targeting DOR could be a potential strategy for managing injury-induced mechanical hypersensitivity.
      Protoporphyrin IX: The Good, the Bad, and the Ugly

      research Protoporphyrin IX: The Good, the Bad, and the Ugly

      138 citations, November 2015 in “Journal of Pharmacology and Experimental Therapeutics”
      Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.
      Psoriasis of the Scalp: Diagnosis and Management

      research Psoriasis of the Scalp: Diagnosis and Management

      128 citations, January 2001 in “American Journal of Clinical Dermatology”
      Coal tar shampoos, salicylic acid, and topical corticosteroids are effective for scalp psoriasis, with Vitamin D3 analogues also showing benefits; severe cases may require stronger medication with more risks.