June 2025 in “Universal library of medical and health sciences.” This study reviewed literature on hair growth and found that external factors like pollution, stress, and nutrition can adversely affect hair, concluding that a multifactorial approach and personalized nutrition monitoring are essential for effective hair loss therapy.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review suggests that hair loss involves a complex interplay of androgen signaling with various regenerative and inflammatory pathways, challenging the view of dihydrotestosterone as the sole cause.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative literature review by LUSTRAO examines the complex biological mechanisms influencing hair growth and loss, highlighting that androgen signalling, while significant, works within a network involving regenerative, inflammatory, and vascular processes, without establishing it as the sole explanation for conditions like androgenetic alopecia.
March 2018 in “Digital Access to Scholarship at Harvard (DASH) (Harvard University)” In this study, chronic stress signals were found to delay hair follicle stem cell activation and negatively impact their niche components in rodents.
July 2022 in “Journal of Investigative Dermatology” This study found that Substance P increased mitochondrial activity and biogenesis markers in cultured human scalp hair follicles, suggesting a novel link between stress-related neuropeptide signaling and hair follicle mitochondrial responses.
This study found that some white or grey human hairs can naturally regain pigmentation, suggesting a potential temporary reversibility of hair greying associated with stress and molecular changes.
49 citations
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April 2016 in “International journal of molecular sciences” This study found that shift nurses exhibited lower circadian variations compared to daytime nurses, indicating an adjustment of their biological clocks to continuous shift schedules.
224 citations
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March 2006 in “Seminars in Cutaneous Medicine and Surgery” This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.
117 citations
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November 2006 in “Experimental Dermatology” This review explores the biology of wool follicles and suggests their potential use as research models in modern biology, but it reports no new findings.
September 2026 in “Journal of Aesthetic Medicine” This review discusses the various determinants of hair quality in healthy individuals and reports no new clinical results; the authors emphasize the need for independent trials with standardized outcomes.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper proposes an integrated model suggesting that psychological stress, sleep disturbances, nutrition, lifestyle, and various biological factors collectively influence hair health, including hair loss and premature greying.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study synthesizes evidence on the complex interplay between stress, sleep, nutrition, lifestyle, and systemic health and their impact on hair health, encompassing premature greying, hair loss, and follicle cycling.
February 2026 in “International Journal of Molecular Sciences” In this review, researchers discuss how mitochondria-targeted biophysical priming of autologous biologics, through methods like photobiomodulation and ultrasound, can potentially enhance skin rejuvenation and wound repair by modulating mitochondrial function in skin cells.
January 2026 in “Annals of Clinical Endocrinology and Metabolism” This narrative review summarizes evidence on NAD⁺ biosynthesis and turnover, highlighting that while NAD⁺ precursors like NR and NMN consistently boost NAD⁺ levels in preclinical and human studies, clinical outcome results remain varied, indicating a need for more standardized human trials.
43 citations
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March 2011 in “Journal of psychosomatic research” This study found that children with alopecia areata experienced more stressful life events and excreted higher levels of catecholamines compared to healthy siblings.
43 citations
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January 2016 in “Oxidative medicine and cellular longevity” This review discusses the biological effects and mechanisms of THSG in antiaging and related disease treatments but reports no new experimental findings.
15 citations
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January 2017 in “Pigment International” This article reviews the pathogenesis and treatment approaches for premature graying of hair, noting the unsatisfactory options currently available, and reports no new clinical findings.
13 citations
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January 2016 in “Annals of Dermatology” This study found that acute stress in rats inhibits hair growth, likely through increased cortisol levels and activation of the substance P-mast cell pathway.
6 citations
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July 2023 in “Diabetology” This study in an animal model found that Rigenera® technology's use of autologous micrografts improved wound healing in diabetic rats by increasing factors like VEGF-A, IL4, and IL10 while reducing TNF-α and oxidative stress.
3 citations
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June 2024 in “International Journal of Molecular Sciences” In this review, the potential role of the hormone prolactin in skin biology and its implications for treating skin diseases and hair disorders are explored, with a focus on its stress-related impacts and possible immunomodulatory function in the context of COVID-19.
July 2026 in “Clinics in Dermatology” This review discusses the potential benefits of topical melatonin in aesthetic dermatology, including its antioxidant and protective properties for skin aging and photoaging, while also noting varying strengths of evidence across different skin conditions.
This study identified pectin in early immature durian fruits and found that pectin-oligosaccharides derived from them show stronger antioxidant and antiglycation activities, with potential applications in cosmetic products.
July 2024 in “Nursing Research” This study highlights the use of hair and fingernail cortisol levels as retrospective indicators of chronic stress, particularly in minoritized populations facing social stressors that increase the risk of mental health issues.
3 citations
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October 2021 in “Indian Journal of Plastic Surgery” The authors concluded that pattern hair loss is a complex condition with limited treatment efficacy and two FDA-approved drugs, finasteride and minoxidil, to slow its progression.
1 citations
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October 2022 in “Annual review of cell and developmental biology” This review discusses the roles of peripheral nerves in stem cell and immune responses within the skin and hematopoietic system, emphasizing their potential in developing new therapies; it reports no new experimental results.
February 2026 in “International Research Journal of Modernization in Engineering Technology and Science” The researchers emphasize the limited scope of existing studies on lip aging, highlighting issues that include collagen loss and the deepening of lip lines with age, and suggesting a need for further research to guide cosmetic and clinical interventions.
February 2026 in “Psychoneuroendocrinology” Hair cortisol concentration partly reflects HPA axis regulation but doesn't capture all its complexities.
February 2026 in “Journal of Craniofacial Surgery Open” This narrative review outlines the biological costs of hair extensions, such as traction leading to hair loss and scalp issues, and suggests a prevention-focused model involving risk assessment, surveillance, and tiered therapies to minimize alopecia risk and maintain scalp health.
April 2025 in “Diagnostics” This review synthesizes data suggesting that managing inflammation and oxidative stress may enhance the effectiveness of PRP therapy for hair regeneration, though standardizing PRP protocols remains challenging.
In this study, researchers found that both minoxidil and finasteride, commonly used for treating androgenetic alopecia, pose risks to male reproductive health due to their endocrine-disrupting effects and impact on testicular morphology and function, suggesting the need for further research into their reproductive safety.