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Glossary Stratified Epithelium

Stratified epithelium is a type of tissue composed of multiple layers of cells, providing a protective barrier in various parts of the body, including the skin and mucous membranes. In the context of hair biology, stratified epithelium is relevant as it forms the outer layer of the hair follicle, contributing to the structural integrity and health of hair. Key distinguishing characteristics include its ability to regenerate quickly and its role in protecting underlying tissues from mechanical stress, pathogens, and dehydration.

Related Terms

Oral Mucosa

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research Histochemical evidence of mucosubstances in the metaplastic epidermis and hair follicles produced in vitro in the presence of excess vitamin A

20 citations , February 1977 in “The anatomical record”

This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.

research Histology, lectin histochemistry and ultrastructure of interdigital gland in crossbred sheep

3 citations , December 2020

This study investigated the interdigital glands in sheep, highlighting their apocrine sweat glands' ultrastructural characteristics and positive lectin reaction, but reported no new clinical results.

research Histomorphological study on the teat (mammary papilla) of Indian buffalo

7 citations , January 1995 in “The Indian Journal of Animal Sciences”

This study observed that buffalo teats have a melanin-rich epidermis, no hair follicles, and a complex structure with specific epithelial and muscular characteristics.

research Histological Study for Skin of Horse

February 2023 in “Mağallaẗ Tikrīt li-l-ʻulūm al-ṣirfaẗ/Tikrit journal of pure science”

In this study, the researchers reported the detailed anatomical structure of horse skin, including the composition and organization of the epidermis, dermis, and associated glands and follicles.

research The Dermis of Millivora Capenesis

February 2019 in “American International Journal of Humanities Arts and Social Sciences”

This histological study of Millivora Capenesis skin describes the composition of the dermis, featuring distinct papillary and reticular layers with associated structures like hair follicles, glands, and corpuscles.

research Boosting and Rescuing Epidermal Superior Population from Fresh Keratinocyte Cultures

15 citations , August 2013 in “Stem Cells and Development”

This study proposes a two-step method that may enhance the generation of stem-like epidermal cells with superior proliferation and differentiation potential for skin regeneration.

research Scaffolds for epithelial and hair follicle regeneration

1 citations , January 2019 in “Elsevier eBooks”

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

research Epithelial‐to‐mesenchymal transition in cutaneous wound healing: Where we are and where we are heading

141 citations , August 2017 in “Developmental Dynamics”

This review discusses the cellular and molecular changes involved in cutaneous wound re-epithelialization and EMT, highlighting their similarities and differences, but reports no new clinical results.

research Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence

8 citations , November 2020 in “Nature Communications”

This study demonstrates that Tp63-expressing epithelial stem cells from non-skin tissues can respond to skin morphogenetic signals and contribute to the formation of hair follicles, sebaceous glands, and epidermis.

research In vivo imaging of mammary epithelial cell dynamics in response to lineage-biased Wnt/β-catenin activation

1 citations , June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that β-catenin stabilization in specific mammary epithelial lineages leads to cellular changes and the formation of hyperplastic lesions, revealing its role in initiating mammary neoplastic development.

research Epithelial loss of mitochondrial oxidative phosphorylation leads to disturbed enamel and impaired dentin matrix formation in postnatal developed mouse incisor

3 citations , December 2020 in “Scientific reports”

This study found that mitochondrial oxidative phosphorylation in epithelial cells is necessary for proper enamel formation and odontoblast differentiation in developing incisor teeth in K320E-Twinkle Epi mice.

research Epithelial–mesenchymal transition in cutaneous fibrosis disease: from mechanisms to therapy

June 2026 in “Frontiers in Immunology”

This review discusses the role of epithelial–mesenchymal transition in cutaneous fibrotic disorders and highlights potential molecular targets for therapy, but reports no new clinical results.

research Pilar Cyst From a Maxillofacial Surgeon’s Perspective: A Case Report and Review of Literature

1 citations , May 2023 in “Curēus”

In this case report, a rare pilar cyst was found in the left temporal region of a 75-year-old male, highlighting the potential for such cysts to mimic temporal space infections and complicate treatment plans.

research The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer

9 citations , May 2019 in “Experimental Cell Research”

This study found that Hedgehog signaling likely contributes to cervical carcinogenesis, and while itraconazole reduced growth in mice, it did so through pathways other than inhibiting Hedgehog signaling.

research Early inductive events in ectodermal appendage morphogenesis

160 citations , January 2014 in “Seminars in cell & developmental biology”

This review discusses the shared molecular and cellular processes in the early development stages of skin appendages like hair follicles, teeth, and mammary glands, reporting no new results.

research Endogenous human skin equivalent promotes in vitro morphogenesis of follicle-like structures

36 citations , May 2016 in “Biomaterials”

This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.

research Molecular Regulation and Cellular Heterogeneity in Skin Repair and Hair Follicle Regeneration

January 2019

This dissertation reported that the loss of Ovol2 impairs hair follicle regeneration and wound repair in mice, highlighting its role in regulating directional migration of epithelial cells.

research Molecular stratification of the human fetal vaginal epithelium by spatial transcriptome analysis

1 citations , April 2024 in “Acta Biochimica et Biophysica Sinica”

This study categorizes the human fetal vaginal epithelium into four areas with distinct transcriptomic profiles, aiding potential advancements in vaginal reconstruction and drug delivery.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations , August 2020 in “Cells”

This review discusses the role of TGM3 in skin and hair follicle biology, human tumor pathology, and genetic abnormalities, and reports no novel results; the authors highlight its potential as a cancer diagnostic biomarker.

research Subepithelial superficial lymph vessels in the airway: a histological study using human fetuses and elderly cadavers

October 2025 in “Folia Morphologica”

This study found that lymph vessel morphology and density in airways differed based on location and type of epithelium, with the highest density in the ciliated epithelium of the nasal passages and site-specific patterns apparent in both fetal and adult specimens.

research Orai1 expression pattern in tooth and craniofacial ectodermal tissues and potential functions during ameloblast differentiation

15 citations , July 2015 in “Developmental Dynamics”

This study highlights the role of Orai1 in ameloblast differentiation and maturation, showing that its down-regulation affects cell proliferation and enamel formation during tooth development.

research Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury

57 citations , December 2021 in “Nature Communications”

In this study, enteroendocrine cells were shown to coordinate intestinal stem cell migration towards a wound in Drosophila by releasing a ligand that activates non-canonical Wnt signaling, aiding efficient tissue repair.

research Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture

2 citations , February 2024 in “Nature cell biology”

In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.

research An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis

November 2024 in “The Journal of Cell Biology”

This study revealed that basement membrane dynamics are crucial to hair follicle development, influencing progenitor cell behavior and cell division patterns in developing mouse hair follicles.

research Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

363 citations , March 2017 in “Nature Communications”

This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.

research Cutaneous Adnexal Cysts Revisited: What We Know and What We Think We Know

13 citations , June 2018 in “Dermatopathology”

This classification proposal introduces a novel system for categorizing cutaneous adnexal cysts based on their origin in the folliculosebaceous unit and sweat glands, aiming to simplify and enhance understanding of these skin lesions.

research Effects of 1?,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsoriatic drugs

10 citations , October 1993 in “Archives of dermatological research”

The researchers reported that the antipsoriatic compounds 1,25-dihydroxy-vitamin D3 and calcipotriol thinned the living cell compartment in organotypic ORS cultures by accelerating the differentiation pathway rather than affecting proliferation.

research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16

53 citations , September 1999 in “The journal of cell biology/The Journal of cell biology”

In this study, expressing human K16 in the epidermis of K14 null mice prevented early skin blistering but led to age-related anomalies, indicating K16 and K14 have distinct roles despite their sequence similarity.

research Anatomy and Function of the Skin

40 citations , January 2016 in “Elsevier eBooks”

This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.

research Clinicopathological study of cutaneous adnexal cyst with some unusual presentation

2 citations , September 2021 in “Journal of Pathology of Nepal”

This study found that cutaneous cysts most frequently appeared as epidermal cysts, with unusual locations posing diagnostic challenges that required histopathological analysis for definitive diagnosis.