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Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

The androgen receptor's shape-changing ability helps it function but can lead to cancer treatment resistance.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

Ginseng, especially red ginseng, may help regrow hair and block a hair loss-related enzyme.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Compound 4 is a promising treatment for hair loss with low toxicity.

New treatments for male hypogonadism are effective and should be personalized.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Finasteride may improve prostate cancer treatment outcomes.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

Bicalutamide may help treat female pattern hair loss.

Scientists found new nonsteroidal compounds that can act like natural male hormones and might help treat male fertility and hormone issues.

The vitamin D receptor can work without its usual activating molecule.