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Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

VDR regulation varies by tissue and is crucial for its biological functions.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

Mice without active or present vitamin D receptors maintain normal blood sugar control and islet gene expression when calcium levels are normal.

PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

Vitamin D receptor is crucial for bone health and mineral metabolism.

Too much androgen can cause hair loss; finasteride may help.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Finasteride reduces alcohol withdrawal effects, especially in female mice.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

Finasteride effectively treats central serous chorioretinopathy.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

A patient with granuloma annulare experienced both isotopic and isomorphic responses, with skin lesions responding to steroids but relapsing after stopping treatment.

Eating high-glycemic and dairy foods can increase hormones that may cause acne and other health issues.

The document concludes that new treatments for skin conditions are complex but effective, including spironolactone for female hair loss and propranolol for infantile hemangiomas.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

New compounds with carborane showed anti-androgen effects similar to flutamide.

Rosemary extracts with carnosic acid and carnosol can reduce the harmfulness of Staphylococcus aureus without stopping its growth.

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.

Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.

JAK inhibitors helped treat hair loss in two people with Down syndrome.