December 2022 in “JAMA network open” 5α-Reductase inhibitors may increase depression risk but not dementia or suicide.
408 citations,
May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.
1 citations,
July 2022 in “Frontiers in Pharmacology” Dutasteride may help protect neurons and reduce inflammation in Parkinson's disease.
10 citations,
August 1998 in “Journal of Investigative Dermatology” The compounds tested could potentially treat hair loss and alopecia.
46 citations,
October 2012 in “Dermatologic Clinics” Female pattern hair loss diagnosed by scalp appearance, treated with combined therapies and targeted approaches.
31 citations,
January 2003 in “Dermatology” Steroidogenic isoenzymes may help improve treatments for common hair loss.
January 2017 in “Cogent Medicine” Extracts improve hair growth in alopecia.
34 citations,
May 2012 in “International Journal of Molecular Sciences” Dieckol from Ecklonia cava may help hair growth and could be a potential hair loss treatment.
59 citations,
November 2018 in “Psychoneuroendocrinology” Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.
Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.
February 2024 in “Brain research bulletin” Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.
58 citations,
January 2006 in “Skin Pharmacology and Physiology” High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.
123 citations,
December 2015 in “Journal of Neuroendocrinology” New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.
8 citations,
July 2014 in “General and Comparative Endocrinology” Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
13 citations,
July 2018 in “General and comparative endocrinology” Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.
6 citations,
January 2021 in “International Journal of Molecular Sciences” Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.
33 citations,
January 2002 Latanoprost, a glaucoma drug, showed potential for promoting hair growth in bald monkeys, especially at higher doses.
11 citations,
November 2012 in “Seminars in Cutaneous Medicine and Surgery” Genetic factors affect hair loss, and molecular testing may help predict, diagnose, and treat it.
17 citations,
January 2020 in “The World Journal of Men's Health” Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.
10 citations,
May 2018 in “Neuropharmacology” Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
115 citations,
September 2012 in “Experimental Dermatology” Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.
43 citations,
July 2018 in “Journal of The European Academy of Dermatology and Venereology” Finasteride and minoxidil mix works better for hair growth than minoxidil alone, with similar safety.
12 citations,
October 2012 in “Dermatologic Clinics” Low-Level Laser Therapy and other light treatments for hair growth lack strong evidence and need more research.
581 citations,
October 1998 in “Journal of The American Academy of Dermatology” Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.
26 citations,
December 2015 in “Journal of The European Academy of Dermatology and Venereology” New method measures female hair loss: Female Pattern Hair Loss Severity Index (FPHL-SI).
25 citations,
April 2006 in “British Journal of Dermatology” Finasteride lowers scalp and blood DHT levels, potentially treating male-pattern baldness.
239 citations,
November 2000 in “Journal of The American Academy of Dermatology” Finasteride doesn't effectively treat hair loss in postmenopausal women.
139 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Androgenetic alopecia in women needs more research and better management strategies.
55 citations,
July 2016 in “Dermatologic Therapy” Multiple treatments work best for hair loss.
8 citations,
September 2008 in “Medical Hypotheses” The paper suggests that hair loss might be caused by skull growth, not just DHT's effect on hair follicles, and calls for more research.