November 2012 in “Transplantation” This study suggests that large corneal stem cells isolated from the stratum corneum may be capable of covering central wound areas when transplanted onto granulation tissue.
This study found that hoof progenitor cells from fresh equine tissue have multilineage differentiation capabilities, offering insights for future progenitor cell-based hoof and dermal-epidermal tissue engineering.
21 citations
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June 2018 in “Current Opinion in Genetics & Development” This review discusses recent advancements in regenerative medicine, including functional organ regeneration and the creation of mini-organs, and reports no new clinical results.
August 2019 in “Journal of Investigative Dermatology” This study found that the desmosomal protein desmoplakin is crucial for proper epidermal morphogenesis and radial intercalation in developing Xenopus embryos, affecting keratin organization and ectodermal structures.
9 citations
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March 2013 in “ISRN Stem Cells (Online)” This study demonstrated that human dermal mesenchymal stem cells can be differentiated into cardiomyocytes using 5-azacytidine, suggesting potential future applications for treating myocardial infarction.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that targeting the tumor stroma to promote the formation of dermal condensates may offer a novel approach to treating basal cell carcinoma.
May 2026 in “Scientific Reports” This study explored the potential of stigmasterol as a treatment for androgenetic alopecia through various simulation techniques, finding promising interactions with key genes involved in hair loss, but further experimental validation is needed before clinical application.
January 2018 in “VCU Scholars Compass (Virginia Commonwealth University)” In this study using Xenopus laevis embryos, reduced levels of the desmosomal protein desmoplakin led to defects in epidermal and cardiac structures, suggesting its crucial role in tissue integrity.
1 citations
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July 2022 in “Pakistan biomedical journal” This review discusses ethanol-based transethosome vesicles for drug delivery through the skin, but reports no new clinical results.
April 2023 in “Journal of Investigative Dermatology” In this study using a mouse model of Pemphigus vulgaris, researchers found that loss of desmoglein 3 adhesion in hair follicle stem cells triggers a regenerative program restoring stem cell function, requiring Hedgehog pathway suppression.
11 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” This study reviewed the prospects and challenges of using stem cells from adipose tissue in regenerative medicine for facial rejuvenation, emphasizing the need for further research to ensure patient safety before these methods can become routine in cosmetic and reconstructive surgery.
10 citations
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November 2019 in “Cold Spring Harbor Perspectives in Biology” This review discusses how recent advances in live imaging have revealed the dynamic and adaptable nature of stem cells during various biological processes, and reports no clinical results.
45 citations
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August 2023 in “Trends in Cell Biology” This review highlights the potential of in vivo reprogramming using OSKM transcription factors for developing rejuvenating and regenerative strategies, while noting the associated risk of tumorigenicity and discussing how improved understanding could lead to safer applications.
July 2025 in “Journal of Investigative Dermatology” 17 citations
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February 2020 in “Cell and Tissue Banking”
November 2022 in “Journal of Investigative Dermatology” This study found that dysregulation of the DNA damage response in stem cells is a common factor of aging, affecting tissues like the skin, brain, kidneys, and intestine.
1 citations
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January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that knocking out vinculin in mouse skin disrupts bulge stem cell quiescence by impairing force generation and mechanical stability of adherens junctions.
44 citations
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January 2023 in “New Phytologist” This study found that low temperature triggers root hair elongation in Arabidopsis thaliana through a FERONIA-ROP2-TORC signaling pathway, also activated by nitrogen deficiency.
November 2019 in “SLAS technology” This study demonstrates that Sox11 and Sox4 are crucial for activating embryonic-like programs during wound healing, with Sox11 overexpression impairing skin differentiation and promoting genes linked to embryonic epidermis.
4 citations
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April 2019 in “Cell Stem Cell” This study found that a specific macrophage subpopulation in the dermis helps maintain hair follicle stem cell quiescence through cytokine-mediated signaling.
27 citations
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May 2011 in “Current Opinion in Ophthalmology” This study reports that a new transplantation technique using tissue-engineered stem cells successfully reconstructed corneal epithelium in an animal model of severe ocular surface disease.
4 citations
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October 2020 in “Journal of oral and maxillofacial surgery” This review discusses the use of Tisseel for stabilizing particulate grafts and reports no new clinical results; the authors emphasize the need for further controlled trials.
18 citations
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June 2011 in “Cell stem cell” Two studies in Cell Stem Cell reported that human and mouse somatic cells can be reprogrammed into induced pluripotent stem cells using microRNAs, eliminating the need for ectopic protein expression.
22 citations
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October 2020 in “Frontiers in Cell and Developmental Biology” This study found that resveratrol and fisetin promoted hair growth in mice by inducing telomerase reverse transcriptase expression, which activates hair follicle stem cells and transitions follicles from a resting to a growth phase.
November 2024 in “DELOS Desarrollo Local Sostenible” In this study, researchers observed that Thunbergia grandiflora and Russelia equisetiformis exhibited mutual aid by altering their phenotypic characteristics to facilitate intertwining, suggesting a form of solidarity without apparent external threats.
April 2023 in “Journal of Investigative Dermatology” This report details the development of a PSR™ Terminalia extract with antioxidant and anti-aging potential, highlighting its rich composition in phenolic acids, polysaccharides, and organic acids, without new clinical results.
8 citations
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February 2021 in “Journal of Clinical Medicine” This study found that mesenchymal stem cells sourced from hair follicle outer root sheath showed higher differentiation efficiency and angiogenic potential for vascular graft applications compared to adipose-derived stem cells.
9 citations
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March 2013 in “Expert opinion on biological therapy” This article reviews recent research on adult epidermal stem cells, discussing their properties and potential for reprogramming into patient-specific therapies, and emphasizes the need for further development while minimizing cancer risk.
14 citations
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March 2021 in “Regenerative Biomaterials” This study found that incorporating cell-adhesive ligands into 3D peptide hydrogels supports the survival and osteogenic differentiation of human amniotic mesenchymal stem cells.
This article reviews the current understanding of the localization, characteristics, and potential markers of epidermal stem cells, and reports no new experimental results.