Review Use of Tisseel, a Fibrin Sealant, for Particulate Graft Stabilization

The article reviewed the use of Tisseel, a fibrin sealant, for stabilizing particulate bone grafts, comparing it with PRP, L-PRF, and resorbable membranes. It highlighted Tisseel's advantages, such as its ability to maintain graft shape longer due to aprotinin, ease of use without requiring blood draw or centrifuge, and comparable cost to other methods. Two case reports demonstrated successful ridge augmentation using Tisseel. However, the authors noted limitations, including a small sample size and incomplete treatment in one case, concluding that more clinical trials are needed to validate Tisseel's superiority.