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Box A of HMGB1 can improve stem cell function, aiding anti-aging therapy.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

Fat-derived stem cells can help protect and repair skin stem cells from aging caused by UV light.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Aging causes skin stem cells to work less effectively.

Activating β-catenin in mammary cells leads to changes that cause early-stage abnormal growths similar to skin structures.

Metabolism plays a key role in determining stem cell fate.

Stem cell therapy shows promise in improving burn wound healing.

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.

The lentiviral array can monitor and predict gene activity during stem cell differentiation.

Myc activation reduces skin stem cells by affecting cell adhesion.

Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.

Eating less can improve stem cell function and increase lifespan.

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

Cells lacking the Bax protein can outcompete others, leading to better tissue repair and hair growth.

Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

Adult stem cells with Tp63 can form hair and skin cells when placed in new skin, showing they have hidden abilities for skin repair.

Metabolic signals and cell shape influence how cells develop and change.